Association of body mass index with risk of cognitive impairment and dementia: A systematic review and meta-analysis of prospective studies

• Published in: Neuroscience and biobehavioral reviews Vol. 115; pp. 189 - 198
• Main Authors: Qu, Yi, Hu, He-Ying, Ou, Ya-Nan, Shen, Xue-Ning, Xu, Wei, Wang, Zuo-Teng, Dong, Qiang, Tan, Lan, Yu, Jin-Tai
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.08.2020
• Subjects: Alzheimer’s disease; Body Mass Index; Cognitive Dysfunction - epidemiology; cognitive impairment; dementia; Dementia - epidemiology; dose-response; Humans; meta-analysis; Prospective Studies; Risk Factors; vascular dementia; Alzheimer’s disease; body mass index; vascular dementia; meta-analysis; dose-response; dementia; cognitive impairment

•Midlife underweight, midlife obesity and late-life underweight increase dementia risk.•Late-life overweight and obesity conferred 21% and 25% reduced dementia risk.•ACD risk in midlife was significantly elevated when BMI surpassed 29 kg/m2.•AD risk in midlife was significantly elevated when BMI sur...