Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2′-deoxyguanosine by high-performance liquid chromatography–electrospray tandem mass spectrometry as a measure of oxidative stress - Malayappan, Bhaskar; Garrett, Timothy J.; Segal, Mark; Leeuwenburgh, Christiaan (Journal of Chromatography A, 2007)
Keywords: 8-Oxo-2′-deoxyguanosine (8-oxodG); 8-Oxoguanine (8-oxoGua); 8-Oxoguanosine (8-oxoGuo); Biological and medical sciences; Carbon Isotopes - chemistry; Carbon Isotopes - standards; Chromatography, High Pressure Liquid - methods; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; DNA biomarkers; DNA Damage; Fapy-guanine (Fapy-Gua); Guanine - analogs & derivatives; Guanine - urine; Guanosine - analogs & derivatives; Guanosine - urine; HPLC–tandem mass spectrometry; Humans; Indicator Dilution Techniques - statistics & numerical data; Kidney Failure, Chronic - urine; Medical sciences; Molecular Structure; Nitrogen Isotopes - chemistry; Nitrogen Isotopes - standards; Nucleic acids; Oxidation-Reduction; Oxidative stress; Oxidative Stress - physiology; Pyrimidines - urine; Reference Standards; Renal disease; Smoking - urine; Spectrometry, Mass, Electrospray Ionization - methods; Tandem Mass Spectrometry - methods; Tobacco, tobacco smoking; Toxicology; HPLC–tandem mass spectrometry; Oxidative stress; 8-Oxo-2′-deoxyguanosine (8-oxodG); DNA biomarkers; Fapy-guanine (Fapy-Gua); 8-Oxoguanine (8-oxoGua); 8-Oxoguanosine (8-oxoGuo); Renal disease; Nucleic acids; Biological fluid; Purine nucleoside; 8- Oxoguanosine (8-oxoGuo); Chemical analysis; HPLC-tandem mass spectrometry; RNA; HPLC chromatography; Biological marker; Deoxyribonucleoside; 8-Oxo-2'-deoxyguanosine (8-oxodG); Electrospray; Smoker; Clinical biology; Oxidation; Quantitative analysis; Kidney disease; Human; Urine; Urinary system disease; Coupled method; Reaction product; Elimination; Isotope dilution; Patient; Non smoker; Reversed phase chromatography; Deoxyguanosine; Nephropathy; DNA; Guanine derivatives; Mass spectrometry MS/MS; Ribonucleoside