Maintaining Life and Health by Natural Selection of Protein Molecules
A concept for a life and health-preserving principle is presented, with reference to evolutionary, medical, and biochemical observations. Life comprises two basic phenomena: it unfolds over longer periods at the population level, and is sustained for the duration of individual life spans. The evolut...
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| Published in | Journal of theoretical biology Vol. 201; no. 1; pp. 75 - 85 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
07.11.1999
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| Subjects | |
| Online Access | Get full text |
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| Abstract | A concept for a life and health-preserving principle is presented, with reference to evolutionary, medical, and biochemical observations. Life comprises two basic phenomena: it unfolds over longer periods at the population level, and is sustained for the duration of individual life spans. The evolution of life within populations by means of natural selection of individuals is central to Darwin's theory of evolution. An important component of maintaining individual life is proposed here to be the natural selection of molecular components—the proteins, a process of preferred removal of denatured and old, synonymous with the selection of younger, functional molecules. The proteins of the cell are committed to fulfilling all the tasks programmed by the genome while continuously maintaining all appropriate cellular functions, including protecting the DNA. Physiological and environmental influences accelerate the breakdown of aged protein molecules, driving this renewal process so that the cell can maintain its protein stock at high-performance levels. The principle of selection makes the incredible dynamics of continual protein turnover, and hence not only the preservation of life, but the maintenance of health in individual beings, comprehensible. Arguments are presented to counter the hypothesis that protein breakdown is a stochastic, random process governed by first-order kinetics. |
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| AbstractList | A concept for a life and health-preserving principle is presented, with reference to evolutionary, medical, and biochemical observations. Life comprises two basic phenomena: it unfolds over longer periods at the population level, and is sustained for the duration of individual life spans. The evolution of life within populations by means of natural selection of individuals is central to Darwin's theory of evolution. An important component of maintaining individual life is proposed here to be the natural selection of molecular components—the proteins, a process of preferred removal of denatured and old, synonymous with the selection of younger, functional molecules. The proteins of the cell are committed to fulfilling all the tasks programmed by the genome while continuously maintaining all appropriate cellular functions, including protecting the DNA. Physiological and environmental influences accelerate the breakdown of aged protein molecules, driving this renewal process so that the cell can maintain its protein stock at high-performance levels. The principle of selection makes the incredible dynamics of continual protein turnover, and hence not only the preservation of life, but the maintenance of health in individual beings, comprehensible. Arguments are presented to counter the hypothesis that protein breakdown is a stochastic, random process governed by first-order kinetics. |
| Author | ARTHUR-GOETTIG, AVRIL PIRLET, KARL |
| Author_xml | – sequence: 1 givenname: KARL surname: PIRLET fullname: PIRLET, KARL organization: Johann Wolfgang Goethe-University of Frankfurt, Zentrum der Inneren Medizin, Theodor-Stern-Kai 7, D-60596, Frankfurt, Germany – sequence: 2 givenname: AVRIL surname: ARTHUR-GOETTIG fullname: ARTHUR-GOETTIG, AVRIL organization: Bioscript, Roemerstrasse 25, D-80801, Munich, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/10534437$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_clinbiochem_2004_07_011 crossref_primary_10_1016_j_mehy_2006_10_056 |
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| SubjectTerms | Animals Biological Evolution Cell Death Half-Life Health Humans Mice Protein Folding Proteins - genetics Proteins - metabolism Selection, Genetic Space life sciences |
| Title | Maintaining Life and Health by Natural Selection of Protein Molecules |
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