Cyclooxygenase (COX)-2-dependent effects of the inhibitor SC236 when combined with ionizing radiation in mammary tumor cells derived from HER-2/neu mice

• Published in: Molecular cancer therapeutics Vol. 3; no. 4; pp. 417 - 424
• Main Authors: Lanza-Jacoby, Susan, Dicker, Adam P, Miller, Sheldon, Rosato, Francis E, Flynn, John T, Lavorgna, Stephanie N, Burd, Randy
• Format: Journal Article
• Language: English
• Published: United States American Association for Cancer Research 01.04.2004
• Subjects: Animals; Cell Division - drug effects; Cell Division - radiation effects; Cell Line, Tumor; Cell Survival - drug effects; Cell Survival - radiation effects; Culture Media, Conditioned - metabolism; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors - pharmacology; Dinoprostone - pharmacology; Genes, erbB-2 - genetics; Genes, erbB-2 - physiology; Isoenzymes - genetics; Isoenzymes - metabolism; Mammary Neoplasms, Animal - drug therapy; Mammary Neoplasms, Animal - genetics; Mammary Neoplasms, Animal - pathology; Mammary Neoplasms, Animal - radiotherapy; Mice; Mice, Transgenic; Prostaglandin-Endoperoxide Synthases - genetics; Prostaglandin-Endoperoxide Synthases - metabolism; Pyrazoles - antagonists & inhibitors; Pyrazoles - pharmacology; Radiation, Ionizing; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sulfonamides - antagonists & inhibitors; Sulfonamides - pharmacology; Vascular Endothelial Growth Factor A - metabolism; Vascular Endothelial Growth Factor A - secretion

Cyclooxygenase (COX)-2-derived prostaglandins (PGs) are thought to contribute to tumor growth and resistance to radiation therapy. COX-2 protein expression is increased in many tumors including those of the breast. COX-2-derived PGs have been shown to protect cells from radiation damage. This study...