Differential network analysis depicts regulatory mechanisms for hepatocellular carcinoma from diverse backgrounds
To elucidate the integrative combinational gene regulatory network landscape of hepatocellular carcinoma (HCC) molecular carcinogenesis from diverse background. Modified gene regulatory network analysis was used to prioritize differentially regulated genes and links. Integrative comparisons using bi...
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| Published in | Future oncology (London, England) Vol. 15; no. 34; pp. 3917 - 3934 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Future Medicine Ltd
01.12.2019
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| Abstract | To elucidate the integrative combinational gene regulatory network landscape of hepatocellular carcinoma (HCC) molecular carcinogenesis from diverse background.
Modified gene regulatory network analysis was used to prioritize differentially regulated genes and links. Integrative comparisons using bioinformatics methods were applied to identify potential critical molecules and pathways in HCC with different backgrounds.
E2F1 with its surrounding regulatory links were identified to play different key roles in the HCC risk factor dysregulation mechanisms. Hsa-mir-19a was identified as showed different effects in the three HCC differential regulation networks, and showed vital regulatory role in HBV-related HCC.
We describe in detail the regulatory networks involved in HCC with different backgrounds. E2F1 may serve as a universal target for HCC treatment. |
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| AbstractList | To elucidate the integrative combinational gene regulatory network landscape of hepatocellular carcinoma (HCC) molecular carcinogenesis from diverse background.
Modified gene regulatory network analysis was used to prioritize differentially regulated genes and links. Integrative comparisons using bioinformatics methods were applied to identify potential critical molecules and pathways in HCC with different backgrounds.
E2F1 with its surrounding regulatory links were identified to play different key roles in the HCC risk factor dysregulation mechanisms. Hsa-mir-19a was identified as showed different effects in the three HCC differential regulation networks, and showed vital regulatory role in HBV-related HCC.
We describe in detail the regulatory networks involved in HCC with different backgrounds. E2F1 may serve as a universal target for HCC treatment. Aim: To elucidate the integrative combinational gene regulatory network landscape of hepatocellular carcinoma (HCC) molecular carcinogenesis from diverse background. Materials & methods: Modified gene regulatory network analysis was used to prioritize differentially regulated genes and links. Integrative comparisons using bioinformatics methods were applied to identify potential critical molecules and pathways in HCC with different backgrounds. Results: E2F1 with its surrounding regulatory links were identified to play different key roles in the HCC risk factor dysregulation mechanisms. Hsa-mir-19a was identified as showed different effects in the three HCC differential regulation networks, and showed vital regulatory role in HBV-related HCC. Conclusion: We describe in detail the regulatory networks involved in HCC with different backgrounds. E2F1 may serve as a universal target for HCC treatment. |
| Author | Fu, Pei-Yao Xu, Yang Qiu, Shuang-Jian Zhou, Jian Sun, Hai-Xiang Fan, Jia Liu, Ji-Xiang Tang, Wei-Guo Yang, Zhang-Fu Hu, Bo Yu, Min-Cheng Ma, Xiao-Lu |
| AuthorAffiliation | 1Department of Liver Surgery & Transplantation, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis & Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, PR China 5Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai 201199, PR China 3Institute of Biomedical Sciences, Fudan University, Shanghai 200032, PR China 4Department of Laboratory Medicine, Shanghai Cancer Center, Fudan University, Shanghai 200032, PR China 2State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200032, PR China 6Shanghai Center for Bioinformation Technology & Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai Industrial Technology Institute, 1278 Keyuan Road, Shanghai 201203, PR China |
| AuthorAffiliation_xml | – name: 6Shanghai Center for Bioinformation Technology & Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai Industrial Technology Institute, 1278 Keyuan Road, Shanghai 201203, PR China – name: 1Department of Liver Surgery & Transplantation, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis & Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, PR China – name: 3Institute of Biomedical Sciences, Fudan University, Shanghai 200032, PR China – name: 5Institute of Fudan-Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai 201199, PR China – name: 4Department of Laboratory Medicine, Shanghai Cancer Center, Fudan University, Shanghai 200032, PR China – name: 2State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200032, PR China |
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| References | e_1_3_5_29_1 e_1_3_5_27_1 e_1_3_5_25_1 e_1_3_5_23_1 e_1_3_5_44_1 e_1_3_5_46_1 e_1_3_5_48_1 e_1_3_5_3_1 e_1_3_5_40_1 e_1_3_5_42_1 e_1_3_5_9_1 e_1_3_5_21_1 e_1_3_5_5_1 e_1_3_5_7_1 e_1_3_5_18_1 e_1_3_5_39_1 e_1_3_5_16_1 e_1_3_5_37_1 e_1_3_5_14_1 e_1_3_5_35_1 e_1_3_5_12_1 e_1_3_5_33_1 e_1_3_5_50_1 e_1_3_5_52_1 e_1_3_5_54_1 e_1_3_5_10_1 e_1_3_5_31_1 e_1_3_5_28_1 e_1_3_5_26_1 e_1_3_5_24_1 e_1_3_5_45_1 e_1_3_5_47_1 Cao MS (e_1_3_5_22_1) 2015; 5 e_1_3_5_49_1 e_1_3_5_41_1 e_1_3_5_43_1 e_1_3_5_8_1 e_1_3_5_20_1 e_1_3_5_4_1 e_1_3_5_6_1 e_1_3_5_17_1 e_1_3_5_38_1 e_1_3_5_15_1 e_1_3_5_13_1 e_1_3_5_36_1 e_1_3_5_11_1 e_1_3_5_34_1 e_1_3_5_19_1 e_1_3_5_51_1 e_1_3_5_53_1 e_1_3_5_32_1 e_1_3_5_30_1 |
| References_xml | – ident: e_1_3_5_23_1 doi: 10.1016/j.artmed.2017.02.006 – ident: e_1_3_5_44_1 doi: 10.1111/jgh.14262 – ident: e_1_3_5_28_1 doi: 10.1093/nar/gkt1181 – ident: e_1_3_5_18_1 doi: 10.1038/nature11981 – ident: e_1_3_5_29_1 doi: 10.1093/bioinformatics/btr260 – ident: e_1_3_5_16_1 doi: 10.1186/gm340 – ident: e_1_3_5_26_1 doi: 10.1093/database/bau093 – ident: e_1_3_5_40_1 doi: 10.1093/nar/gku1075 – ident: e_1_3_5_51_1 doi: 10.1016/j.molonc.2012.04.001 – ident: e_1_3_5_15_1 doi: 10.1186/1752-0509-6-61 – ident: e_1_3_5_36_1 doi: 10.1093/nar/gkv1258 – ident: e_1_3_5_14_1 doi: 10.1038/nrg3575 – ident: e_1_3_5_53_1 doi: 10.1038/emm.2015.126 – ident: e_1_3_5_42_1 doi: 10.1126/science.aaa1738 – ident: e_1_3_5_4_1 doi: 10.1053/j.gastro.2015.12.041 – ident: e_1_3_5_39_1 doi: 10.1093/nar/gkp638 – ident: e_1_3_5_52_1 doi: 10.1080/15476286.2015.1022702 – ident: e_1_3_5_9_1 doi: 10.1038/s41467-018-04006-0 – ident: e_1_3_5_35_1 doi: 10.1093/database/baw105 – ident: e_1_3_5_50_1 doi: 10.1002/hep.27121 – ident: e_1_3_5_46_1 doi: 10.1002/hep.28972 – ident: e_1_3_5_20_1 doi: 10.1093/bioinformatics/btq471 – ident: e_1_3_5_48_1 doi: 10.1016/j.molonc.2016.05.006 – ident: e_1_3_5_21_1 doi: 10.1371/journal.pone.0079729 – ident: e_1_3_5_8_1 doi: 10.1002/hep.29486 – ident: e_1_3_5_54_1 doi: 10.1016/j.jhep.2006.05.013 – ident: e_1_3_5_25_1 doi: 10.2147/OTT.S135312 – ident: e_1_3_5_41_1 doi: 10.1093/bioinformatics/btu155 – ident: e_1_3_5_37_1 doi: 10.1093/nar/gks1060 – ident: e_1_3_5_17_1 doi: 10.1038/nrc3447 – ident: e_1_3_5_12_1 doi: 10.1016/j.molcel.2015.05.008 – ident: e_1_3_5_27_1 doi: 10.1093/nar/gkq1237 – ident: e_1_3_5_34_1 doi: 10.1007/s00439-001-0615-0 – ident: e_1_3_5_5_1 doi: 10.1038/nrdp.2016.18 – ident: e_1_3_5_10_1 doi: 10.1002/hep.30036 – ident: e_1_3_5_7_1 doi: 10.1016/j.jhep.2016.01.012 – ident: e_1_3_5_49_1 doi: 10.1002/hep.22849 – ident: e_1_3_5_13_1 doi: 10.1038/ng.3458 – ident: e_1_3_5_6_1 doi: 10.1016/j.jhep.2017.02.022 – ident: e_1_3_5_30_1 doi: 10.1016/j.cels.2015.12.004 – ident: e_1_3_5_45_1 doi: 10.1172/JCI87583 – ident: e_1_3_5_11_1 doi: 10.1016/j.molmed.2018.02.006 – ident: e_1_3_5_32_1 doi: 10.1038/srep11432 – ident: e_1_3_5_24_1 doi: 10.2174/1389450118666170724165514 – ident: e_1_3_5_38_1 doi: 10.1093/nar/gkp803 – ident: e_1_3_5_43_1 doi: 10.1073/pnas.1413896112 – ident: e_1_3_5_3_1 doi: 10.3322/caac.21387 – ident: e_1_3_5_31_1 doi: 10.1093/bioinformatics/btq466 – ident: e_1_3_5_19_1 doi: 10.1073/pnas.1423573112 – ident: e_1_3_5_33_1 doi: 10.1186/1752-0509-7-S2-S7 – ident: e_1_3_5_47_1 doi: 10.1016/j.cmet.2015.12.004 – volume: 5 start-page: 2605 issue: 9 year: 2015 ident: e_1_3_5_22_1 article-title: Differential network analysis reveals dysfunctional regulatory networks in gastric carcinogenesis publication-title: Am. J. Cancer Res. contributor: fullname: Cao MS |
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| SubjectTerms | Algorithms Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - virology Computational Biology Datasets Datasets as Topic differential regulation network analysis Disease-Free Survival E2F1 E2F1 Transcription Factor - antagonists & inhibitors E2F1 Transcription Factor - metabolism etiological factor Gastric cancer Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Gene Regulatory Networks Hepacivirus - isolation & purification Hepacivirus - pathogenicity Hepatitis Hepatitis B virus - isolation & purification Hepatitis B virus - pathogenicity hepatocellular carcinoma hsa-mir-19a Humans Kaplan-Meier Estimate Liver - pathology Liver - virology Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - virology MicroRNAs - genetics MicroRNAs - metabolism Pathogenesis Prognosis Risk factors Seeds TCGA database Transcription factors |
| Title | Differential network analysis depicts regulatory mechanisms for hepatocellular carcinoma from diverse backgrounds |
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