High-dose Factor XIII administration induces effective hemostasis for trauma-associated coagulopathy (TAC) both in vitro and in rat hemorrhagic shock in vivo models

• Published in: The journal of trauma and acute care surgery Vol. 85; no. 3; p. 588
• Main Authors: Nagashima, Futoshi, Inoue, Satoshi, Koami, Hiroyuki, Miike, Toru, Sakamoto, Yuichiro, Kai, Keita
• Format: Journal Article
• Language: English
• Published: United States 01.09.2018

Trauma-associated coagulopathy (TAC) is an early and primary complication in severe trauma patients. Factor XIII (FXIII) is reported to stabilize a clot in the late phase of the coagulation cascade. The goal of this study was to investigate whether the administration of FXIII improves the condition...