CRHR1 antagonist alleviated depression-like behavior by downregulating p62 in a rat model of post-stroke depression

• Published in: Experimental neurology Vol. 378; p. 114822
• Main Authors: Liu, Huanhuan, Zhang, Yunfei, Hou, Xiaoli, Zhu, Chuanzhou, Yang, Qianling, Li, Kun, Fan, Lifei, Zhang, Xinyue, Jiang, Xinhui, Jin, Xuejiao, Lei, Hao, Chen, Tengfei, Zhang, Fuping, Zhang, Zhaohui, Song, Jinggui
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2024
• Subjects: Aged; Animals; Autophagy, ubiquitin–proteasome system; Corticotropin-Releasing Hormone - metabolism; CRHR1 antagonist; Depression - drug therapy; Depression - etiology; Depression - metabolism; Disease Models, Animal; Down-Regulation - drug effects; Female; Humans; Keap1-Nrf2-p62 pathway; Kelch-Like ECH-Associated Protein 1 - antagonists & inhibitors; Kelch-Like ECH-Associated Protein 1 - metabolism; Male; Middle Aged; NF-E2-Related Factor 2 - metabolism; Post-stroke depression; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone - antagonists & inhibitors; Receptors, Corticotropin-Releasing Hormone - metabolism; Sequestosome-1 Protein - metabolism; Stroke - complications; Stroke - drug therapy; Stroke - metabolism; Stroke - psychology; Synaptic loss; Synaptic loss; Keap1-Nrf2-p62 pathway; Autophagy, ubiquitin–proteasome system; CRHR1 antagonist; Post-stroke depression

Post-stroke depression (PSD) is a complication of cerebrovascular disease, which can increase mortality after stroke. CRH is one of the main signaling peptides released after activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress. It affects synaptic plasticity by regulati...