WNT5A Expression Increases during Melanoma Progression and Correlates with Outcome

• Published in: Clinical cancer research Vol. 14; no. 18; pp. 5825 - 5832
• Main Authors: DA FORNO, Philip D, PRINGLE, J. Howard, HUTCHINSON, Peter, OSBORN, Joy, QIANG HUANG, POTTER, Linda, HANCOX, Rachael A, FLETCHER, Alan, SALDANHA, Gerald S
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.09.2008
• Subjects: Antineoplastic agents; Biological and medical sciences; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Cytoplasm - metabolism; Dermatology; Disease Progression; Female; Humans; Male; Medical sciences; melanoma; Melanoma - metabolism; Melanoma - pathology; metastasis; Middle Aged; Neoplasm Metastasis; Pharmacology. Drug treatments; Prognosis; progression; Proto-Oncogene Proteins - metabolism; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; survival; Survival Analysis; Tumors of the skin and soft tissue. Premalignant lesions; Wnt Proteins - metabolism; Wnt-5a Protein; WNT5A; Prognosis; Malignant tumor; Gene expression; Malignant melanoma; Tumor progression; Cancer

Purpose: Wnt ligands play a major role in development and are important in cancer. Expression microarray analysis correlates one member of this family, WNT5A, to a subclass of melanomas with increased motility and invasion. There are no large studies of clinical samples primarily addressing the impo...