Mechanisms Involved in the Promoting Activity of Fibroblasts in HTLV-1-Mediated Lymphomagenesis: Insights into the Plasticity of Lymphomatous Cells

• Published in: International journal of molecular sciences Vol. 22; no. 19; p. 10562
• Main Authors: Rigotto, Giulia, Montini, Barbara, Mattiolo, Adriana, Lazzari, Nayana, Piano, Maria Assunta, Remondini, Daniel, Marmiroli, Sandra, Bertacchini, Jessika, Chieco-Bianchi, Luigi, Calabrò, Maria Luisa
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.09.2021; MDPI
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Apoptosis; Aspirin - pharmacology; Cancer; Cell Line; Cells, Cultured; Coculture Techniques; Fibroblasts; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibroblasts - virology; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Neoplastic - genetics; Human T-lymphotropic virus 1 - physiology; Humans; Infections; Jurkat Cells; Kinases; Leukemia; Lymphoma; Lymphoma - drug therapy; Lymphoma - genetics; Lymphoma - virology; Metabolism; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - virology; Phosphorylation; Principal components analysis; Proteins; Signal Transduction - drug effects; Signal Transduction - genetics; Xenograft Model Antitumor Assays - methods; plasticity; HTLV-1; cancer stem cells; lymphomagenesis; ATLL; stemness

Among the mechanisms leading to progression to Adult T-cell Leukaemia/Lymphoma in Human T-cell Leukaemia Virus type 1 (HTLV-1)-infected subjects, the contribution of stromal components remains poorly understood. To dissect the role of fibroblasts in HTLV-1-mediated lymphomagenesis, transcriptome stu...