Structural Remodeling and Mechanical Function in Heart Failure

• Published in: Microscopy and microanalysis Vol. 18; no. 1; pp. 50 - 67
• Main Authors: Leonard, Bridget Louise, Smaill, Bruce Henry, LeGrice, Ian John
• Format: Journal Article
• Language: English
• Published: New York, USA Cambridge University Press 01.02.2012; Oxford University Press
• Subjects: Animals; Cardiovascular disease; Cardiovascular diseases; Collagen; Ejection fraction; Extracellular matrix; Extracellular Matrix - metabolism; Heart - physiology; Heart - physiopathology; Heart failure; Heart Failure - pathology; Heart Failure - physiopathology; Humans; Hypertension; Industrialized nations; Mechanical properties; Mice; Myocardium - pathology; Rats; Special Section: Keystone Meeting on Extracellular Matrix; Wound Healing - physiology; volume overload; hypertensive heart disease; remodeling; ischemic cardiomyopathy; myocardial architecture; biomechanics; extracellular matrix

The cardiac extracellular matrix (ECM) is the three-dimensional scaffold that defines the geometry and muscular architecture of the cardiac chambers and transmits forces produced during the cardiac cycle throughout the heart wall. The cardiac ECM is an active system that responds to the stresses to...