Post-Translational Regulation of Cathepsin B, but not of Other Cysteine Cathepsins, Contributes to Increased Glioblastoma Cell Invasiveness In Vitro

• Published in: Pathology oncology research Vol. 15; no. 4; pp. 711 - 723
• Main Authors: Gole, Boris, Durán Alonso, María Beatriz, Dolenc, Vincenc, Lah, Tamara
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.12.2009; Springer Nature B.V
• Subjects: Adult; Aged; Biomedical and Life Sciences; Biomedicine; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Cancer Research; Cathepsin B - genetics; Cathepsin B - metabolism; Cathepsin L - metabolism; Cathepsins - metabolism; Cell culture; Cell Line, Tumor; Cell Movement - physiology; Collagen - metabolism; Cystatins - metabolism; Drug Combinations; Enzymes; Female; Glioblastoma - metabolism; Glioblastoma - pathology; Humans; Immunology; Laminin - metabolism; Male; Middle Aged; Neoplasm Invasiveness - physiopathology; Oncology; Pathology; Protein Biosynthesis - physiology; Proteoglycans - metabolism; Spheroids, Cellular - metabolism; Tumors; Glioma; Cysteine cathepsins; Proteolysis; Cystatins; Stefins; Brain tumours; Invasion

Cells that migrate away from a central tumour into brain tissue are responsible for inefficient glioblastoma treatment. This migratory behaviour depends partially on lysosomal cysteine cathepsins. Reportedly, the expression of cathepsins B, L and S gradually increases in the progression from benign...