Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects - Hulot, Jean-Sébastien; Bura, Alessandra; Villard, Eric; Azizi, Michel; Remones, Véronique; Goyenvalle, Catherine; Aiach, Martine; Lechat, Philippe; Gaussem, Pascale (Blood, 2006)
Keywords: Adolescent; Adult; Alleles; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - physiology; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Clopidogrel; Cytochrome P-450 CYP2C19; Genotype; Homozygote; Humans; Male; Medical sciences; Mixed Function Oxygenases - genetics; Mixed Function Oxygenases - physiology; Pharmacogenetics; Pharmacology. Drug treatments; Platelet Aggregation - drug effects; Platelet Aggregation Inhibitors - pharmacology; Platelet Function Tests; Polymorphism, Genetic; Ticlopidine - analogs & derivatives; Ticlopidine - pharmacology; Human; Pharmacogenetics; Genetic variability; Healthy subject; Enzyme; Cytochrome P450; Genetics; Clopidogrel; Genotype; Thienopyridine derivative; Antiplatelet agent; Polymorphism