Decreased NK Cell Frequency and Function Is Associated with Increased Risk of KIR3DL Allele Polymorphism in Simian Immunodeficiency Virus-Infected Rhesus Macaques with High Viral Loads

• Published in: The Journal of immunology (1950) Vol. 182; no. 6; pp. 3638 - 3649
• Main Authors: Bostik, Pavel, Kobkitjaroen, Jaruda, Tang, Weining, Villinger, Francois, Pereira, Lara E, Little, Dawn M, Stephenson, Susan T, Bouzyk, Mark, Ansari, Aftab A
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.03.2009
• Subjects: Alleles; Amino Acid Sequence; Animals; Clone Cells; Cohort Studies; Genetic Predisposition to Disease; Humans; K562 Cells; Killer Cells, Natural - immunology; Killer Cells, Natural - pathology; Killer Cells, Natural - virology; Lymphocyte Count; Macaca mulatta; Molecular Sequence Data; Polymorphism, Single Nucleotide - genetics; Receptors, KIR3DL1 - genetics; Risk Factors; Simian Acquired Immunodeficiency Syndrome - genetics; Simian Acquired Immunodeficiency Syndrome - immunology; Simian Acquired Immunodeficiency Syndrome - pathology; Simian Acquired Immunodeficiency Syndrome - virology; Simian Immunodeficiency Virus - growth & development; Simian Immunodeficiency Virus - immunology; Viral Load; Virus Replication - immunology

NK cells have been established as an important effector of innate immunity in a variety of viral infections. In HIV-1 infection in humans, alterations of NK cell function, frequency, and expression of various NK receptors have been reported to be associated with differential dynamics of disease prog...