Compatibility and stability of linezolid injection admixed with three quinolone antibiotics

• Published in: The Annals of pharmacotherapy Vol. 34; no. 9; p. 996
• Main Authors: Zhang, Y, Xu, Q A, Trissel, L A, Williams, K Y
• Format: Journal Article
• Language: English
• Published: United States 01.09.2000
• Subjects: Acetamides - chemistry; Anti-Infective Agents - chemistry; Ciprofloxacin - chemistry; Drug Stability; Levofloxacin; Linezolid; Ofloxacin - chemistry; Oxazolidinones - chemistry

To evaluate the physical compatibility and chemical stability of linezolid 200 mg/100 mL admixed with ciprofloxacin 400 mg, ofloxacin 400 mg, and levofloxacin 500 mg for seven days at 4 and 23 degrees C. The test samples were prepared by adding the required amount of the quinolone antibiotic to bags...