Hyperelongated biglycan: the surreptitious initiator of atherosclerosis

• Published in: Current opinion in lipidology Vol. 19; no. 5; p. 448
• Main Authors: Little, Peter J, Osman, Narin, O'Brien, Kevin D
• Format: Journal Article
• Language: English
• Published: England 01.10.2008
• Subjects: Animals; Atherosclerosis - metabolism; Atherosclerosis - physiopathology; Biglycan; Extracellular Matrix Proteins - metabolism; Extracellular Matrix Proteins - physiology; Humans; Models, Biological; Proteoglycans - metabolism; Proteoglycans - physiology

To outline a role for the dermatan sulfate proteoglycan biglycan and specifically its growth factor modified form having elongated glycosaminoglycan chains as being a primary initiator of atherosclerosis. Antiatherosclerotic therapies have mostly targeted epidemiologically identified, experimentally...