Experimental traumatic brain injury results in estrous cycle disruption, neurobehavioral deficits, and impaired GSK3β/β-catenin signaling in female rats

• Published in: Experimental neurology Vol. 315; pp. 42 - 51
• Main Authors: Fortress, Ashley M., Avcu, Pelin, Wagner, Amy K., Dixon, C. Edward, Pang, Kevin C.H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2019
• Subjects: Acoustic startle response; Animals; Behavior, Animal; beta Catenin - metabolism; Brain Injuries, Traumatic - physiopathology; Brain Injuries, Traumatic - psychology; Brainstem; Cognition Disorders - etiology; Cognition Disorders - psychology; Estradiol - blood; Estrous Cycle; Female; Glycogen Synthase Kinase 3 beta - metabolism; Hippocampus; Hypogonadism; Hypothalamo-Hypophyseal System - physiopathology; Lateral fluid percussion; Luteinizing Hormone - blood; Maze Learning; Memory; Memory, Short-Term; Neurobehavioral; Rats; Rats, Sprague-Dawley; Reflex, Startle; Signal Transduction; Neurobehavioral; Memory; Brainstem; Female; Lateral fluid percussion; Estrous cycle; Acoustic startle response; Hippocampus; Hypogonadism

An estimated 2.8 million traumatic brain injuries (TBI) occur within the United States each year. Approximately 40% of new TBI cases are female, however few studies have investigated the effects of TBI on female subjects. In addition to typical neurobehavioral sequelae observed after TBI, such as po...