Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis

• Published in: Neuroscience and biobehavioral reviews Vol. 123; pp. 203 - 214
• Main Authors: Cao, Bing, Chen, Yan, Ren, Zhongyu, Pan, Zihang, McIntyre, Roger S., Wang, Dongfang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.04.2021
• Subjects: Antipsychotic treatment; Humans; Kynurenic Acid; Kynurenine; Kynurenine pathway; Quinolinic Acid; Schizophrenia; Tryptophan; Schizophrenia; Tryptophan; Kynurenic acid; Antipsychotic treatment; Kynurenine pathway
• ISSN: 0149-7634; 1873-7528; 1873-7528
• DOI: 10.1016/j.neubiorev.2021.01.018

•Forty-two eligible papers with 4,217 participants were included in the analysis.•Lower TRP levels and higher circulating KYN/TRP ratios existed in subjects with SCZ.•Lower KYN levels were associated with medication-free persons with SCZ.•The KYN levels were higher in subjects with SCZ after antipsy...