Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis
•Forty-two eligible papers with 4,217 participants were included in the analysis.•Lower TRP levels and higher circulating KYN/TRP ratios existed in subjects with SCZ.•Lower KYN levels were associated with medication-free persons with SCZ.•The KYN levels were higher in subjects with SCZ after antipsy...
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| Published in | Neuroscience and biobehavioral reviews Vol. 123; pp. 203 - 214 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Ltd
01.04.2021
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0149-7634 1873-7528 1873-7528 |
| DOI | 10.1016/j.neubiorev.2021.01.018 |
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| Abstract | •Forty-two eligible papers with 4,217 participants were included in the analysis.•Lower TRP levels and higher circulating KYN/TRP ratios existed in subjects with SCZ.•Lower KYN levels were associated with medication-free persons with SCZ.•The KYN levels were higher in subjects with SCZ after antipsychotic treatments when compared with baseline.•The current evidence provides valuable insight of the potential roles of KYN pathway in the pathogenesis of SCZ.
The kynurenine (KYN) pathway is postulated to play various roles in immune system dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore the association between six key metabolites of KYN pathway (i.e., tryptophan (TRP), KYN, quinolinic acid (QUIN), and kynurenic acid (KYNA)) and SCZ. Priori Bonferroni adjustments were conducted for multiple comparisons. In total, 42 studies that examined the relationship between the metabolites in KYN pathway mentioned above and SCZ in 4217 participants and nine studies that examined alterations of these metabolites after antipsychotic treatments were included. The results demonstrate that (1) subjects with prescribed medication had significantly higher KYN levels when compared to controls; (2) higher KYN levels in cerebrospinal fluid (CSF), lower plasma KYN levels and higher CSF KYNA levels were associated with SCZ; (3) the KYN levels were higher in subjects with SCZ after antipsychotic treatments when compared with baseline. The evidence provides valuable insight of the potential underlying involvement of the KYN pathway in the pathogenesis of SCZ. |
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| AbstractList | •Forty-two eligible papers with 4,217 participants were included in the analysis.•Lower TRP levels and higher circulating KYN/TRP ratios existed in subjects with SCZ.•Lower KYN levels were associated with medication-free persons with SCZ.•The KYN levels were higher in subjects with SCZ after antipsychotic treatments when compared with baseline.•The current evidence provides valuable insight of the potential roles of KYN pathway in the pathogenesis of SCZ.
The kynurenine (KYN) pathway is postulated to play various roles in immune system dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore the association between six key metabolites of KYN pathway (i.e., tryptophan (TRP), KYN, quinolinic acid (QUIN), and kynurenic acid (KYNA)) and SCZ. Priori Bonferroni adjustments were conducted for multiple comparisons. In total, 42 studies that examined the relationship between the metabolites in KYN pathway mentioned above and SCZ in 4217 participants and nine studies that examined alterations of these metabolites after antipsychotic treatments were included. The results demonstrate that (1) subjects with prescribed medication had significantly higher KYN levels when compared to controls; (2) higher KYN levels in cerebrospinal fluid (CSF), lower plasma KYN levels and higher CSF KYNA levels were associated with SCZ; (3) the KYN levels were higher in subjects with SCZ after antipsychotic treatments when compared with baseline. The evidence provides valuable insight of the potential underlying involvement of the KYN pathway in the pathogenesis of SCZ. The kynurenine (KYN) pathway is postulated to play various roles in immune system dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore the association between six key metabolites of KYN pathway (i.e., tryptophan (TRP), KYN, quinolinic acid (QUIN), and kynurenic acid (KYNA)) and SCZ. Priori Bonferroni adjustments were conducted for multiple comparisons. In total, 42 studies that examined the relationship between the metabolites in KYN pathway mentioned above and SCZ in 4217 participants and nine studies that examined alterations of these metabolites after antipsychotic treatments were included. The results demonstrate that (1) subjects with prescribed medication had significantly higher KYN levels when compared to controls; (2) higher KYN levels in cerebrospinal fluid (CSF), lower plasma KYN levels and higher CSF KYNA levels were associated with SCZ; (3) the KYN levels were higher in subjects with SCZ after antipsychotic treatments when compared with baseline. The evidence provides valuable insight of the potential underlying involvement of the KYN pathway in the pathogenesis of SCZ.The kynurenine (KYN) pathway is postulated to play various roles in immune system dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore the association between six key metabolites of KYN pathway (i.e., tryptophan (TRP), KYN, quinolinic acid (QUIN), and kynurenic acid (KYNA)) and SCZ. Priori Bonferroni adjustments were conducted for multiple comparisons. In total, 42 studies that examined the relationship between the metabolites in KYN pathway mentioned above and SCZ in 4217 participants and nine studies that examined alterations of these metabolites after antipsychotic treatments were included. The results demonstrate that (1) subjects with prescribed medication had significantly higher KYN levels when compared to controls; (2) higher KYN levels in cerebrospinal fluid (CSF), lower plasma KYN levels and higher CSF KYNA levels were associated with SCZ; (3) the KYN levels were higher in subjects with SCZ after antipsychotic treatments when compared with baseline. The evidence provides valuable insight of the potential underlying involvement of the KYN pathway in the pathogenesis of SCZ. The kynurenine (KYN) pathway is postulated to play various roles in immune system dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore the association between six key metabolites of KYN pathway (i.e., tryptophan (TRP), KYN, quinolinic acid (QUIN), and kynurenic acid (KYNA)) and SCZ. Priori Bonferroni adjustments were conducted for multiple comparisons. In total, 42 studies that examined the relationship between the metabolites in KYN pathway mentioned above and SCZ in 4217 participants and nine studies that examined alterations of these metabolites after antipsychotic treatments were included. The results demonstrate that (1) subjects with prescribed medication had significantly higher KYN levels when compared to controls; (2) higher KYN levels in cerebrospinal fluid (CSF), lower plasma KYN levels and higher CSF KYNA levels were associated with SCZ; (3) the KYN levels were higher in subjects with SCZ after antipsychotic treatments when compared with baseline. The evidence provides valuable insight of the potential underlying involvement of the KYN pathway in the pathogenesis of SCZ. |
| Author | Wang, Dongfang Pan, Zihang Cao, Bing Chen, Yan Ren, Zhongyu McIntyre, Roger S. |
| Author_xml | – sequence: 1 givenname: Bing orcidid: 0000-0001-5963-2676 surname: Cao fullname: Cao, Bing email: bingcao@swu.edu.cn organization: Key Laboratory of Cognition and Personality, Faculty of Psychology, Ministry of Education, Southwest University (SWU), Chongqing, 400715, PR China – sequence: 2 givenname: Yan surname: Chen fullname: Chen, Yan organization: Dalla Lana School of Public Health, University of Toronto, 155 College St., Toronto, ON, Canada – sequence: 3 givenname: Zhongyu surname: Ren fullname: Ren, Zhongyu organization: College of Physical Education, Southwest University, Chongqing, PR China – sequence: 4 givenname: Zihang surname: Pan fullname: Pan, Zihang organization: Duke-NUS Medical School, Singapore, Singapore – sequence: 5 givenname: Roger S. surname: McIntyre fullname: McIntyre, Roger S. organization: Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, Canada – sequence: 6 givenname: Dongfang surname: Wang fullname: Wang, Dongfang email: wangdf1989@126.com organization: NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33513412$$D View this record in MEDLINE/PubMed |
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| Keywords | Schizophrenia Tryptophan Kynurenic acid Antipsychotic treatment Kynurenine pathway |
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| Snippet | •Forty-two eligible papers with 4,217 participants were included in the analysis.•Lower TRP levels and higher circulating KYN/TRP ratios existed in subjects... The kynurenine (KYN) pathway is postulated to play various roles in immune system dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore... |
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| SubjectTerms | Antipsychotic treatment Humans Kynurenic Acid Kynurenine Kynurenine pathway Quinolinic Acid Schizophrenia Tryptophan |
| Title | Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis |
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