Field performance of a thin-layer chromatography assay for detection of nevirapine in umbilical cord blood

• Published in: HIV clinical trials Vol. 7; no. 5; p. 263
• Main Authors: Chi, Benjamin H, Lee, Alison, Acosta, Edward P, Westerman, Larry E, Sinkala, Moses, Stringer, Jeffrey S A
• Format: Journal Article
• Language: English
• Published: England 01.09.2006
• Subjects: Algorithms; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - therapeutic use; Chromatography, High Pressure Liquid; Chromatography, Thin Layer - economics; Cost-Benefit Analysis; Female; Fetal Blood - metabolism; HIV; HIV Infections - metabolism; HIV Infections - prevention & control; HIV Infections - transmission; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical - prevention & control; Nevirapine - pharmacokinetics; Nevirapine - therapeutic use; Pregnancy; Pregnancy Complications, Infectious - metabolism; Pregnancy Complications, Infectious - prevention & control; Prospective Studies; Sensitivity and Specificity; Treatment Outcome; Zambia; Zambia

Although cord blood surveillance can measure the effectiveness of nevirapine (NVP)-based programs for the prevention of mother-to-child HIV transmission (PMTCT), it requires the ability to detect nevirapine in plasma. At present, the only validated method is high-performance liquid chromatography (H...