Vagal Innervation and Early Postoperative Ileus in Mice

• Published in: Journal of gastrointestinal surgery Vol. 15; no. 6; pp. 891 - 901
• Main Authors: Mueller, Mario H., Karpitschka, Martina, Gao, Zhirong, Mittler, Sarah, Kasparek, Michael S., Renz, Bernhard, Sibaev, Andrej, Glatzle, Jörg, Li, Yongyu, Kreis, Martin E.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.06.2011; Springer Nature B.V
• Subjects: 2010 SSAT Plenary Presentation; Abdomen; Afferent Pathways - drug effects; Afferent Pathways - physiology; Analysis of Variance; Animals; Gastroenterology; Gastrointestinal Motility - physiology; Ileus - etiology; Ileus - physiopathology; Jejunum - drug effects; Jejunum - innervation; Jejunum - pathology; Jejunum - physiopathology; Laparotomy; Laparotomy - adverse effects; Leukocyte Count; Leukocytes; Male; Medicine; Medicine & Public Health; Mice; Mice, Inbred C57BL; Motility; Postoperative Complications - etiology; Postoperative Complications - physiopathology; Serotonin - pharmacology; Surgery; Time Factors; Vagotomy; Vagus Nerve - physiology; Germany; Postoperative ileus; Sensitivity; Immune response; Vagus

Introduction Postoperative ileus is characterized by infiltrates of leukocytes in the gut wall 24 h after surgery, which is subject to vagal modulation. We hypothesized that vagal modulation is irrelevant during earlier hours of postoperative ileus and aimed to determine whether afferent neuronal fe...