Obesity and immune-checkpoint inhibitors in advanced melanoma: A meta-analysis of survival outcomes from clinical studies

• Published in: Seminars in cancer biology Vol. 91; pp. 27 - 34
• Main Authors: Roccuzzo, Gabriele, Moirano, Giovenale, Fava, Paolo, Maule, Milena, Ribero, Simone, Quaglino, Pietro
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2023
• Subjects: BMI; Humans; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immunotherapy; Melanoma; Melanoma - complications; Melanoma - drug therapy; Obesity; Obesity - complications; Overweight; Overweight - drug therapy; Tumor Microenvironment; Obesity; Immunotherapy; Melanoma; Overweight; BMI

Obesity is a chronic inflammatory condition that has been associated with different types of cancer. However, its role in melanoma incidence, progression, and response to immune-checkpoint-inhibitors (ICI) is still controversial. On the one hand, increased levels of lipids and adipokines can promote...