Microfluidics Biocatalysis System Applied for the Synthesis of N-Substituted Benzimidazole Derivatives by Aza-Michael Addition

• Published in: Catalysts Vol. 12; no. 12; p. 1658
• Main Authors: Jiang, Rong-Kuan, Pan, Yue, Du, Li-Hua, Zheng, Ling-Yan, Sheng, Zhi-Kai, Zhang, Shi-Yi, Lin, Hang, Zhang, Ao-Ying, Xie, Han-Jia, Yang, Zhi-Kai, Luo, Xi-Ping
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.12.2022
• Subjects: Acrylonitriles; Benzimidazoles; Carbonyl compounds; Carbonyls; Catalysis; Catalysts; Chemical properties; Chemical reactions; Continuous flow; Efficiency; Enzymes; Esters; Hypertension; Lipase; Microfluidics; Microreactors; Nitrogen; Pharmaceutical research; Pharmaceuticals; R&D; Reaction time; Research & development; Solvents; Substitutes; Substitution reactions; Substrates; Sustainable development; Synthesis; China

Benzimidazole scaffolds became an attractive subject due to their broad spectrum of pharmacological activities. In this work, a methodology was developed for the synthesis of N-substituted benzimidazole derivatives from benzimidazoles and α, β-unsaturated compounds (acrylonitriles, acrylate esters,...