Expanding the synthesis of new trans-sulfonamide platinum complexes: Cytotoxicity, SAR, fluorescent cell assays and stability studies

In this manuscript, we describe the synthesis of new trans-N-sulfonamide platinum complexes and their antiproliferative activity (GI50, μM) in human solid tumors cells. The structure activity relationships (SAR), with different new synthesized complexes by variation in ligand, halogen and also in th...

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Published inJournal of inorganic biochemistry Vol. 127; pp. 128 - 140
Main Authors del Solar, Virginia, Quiñones-Lombraña, Adolfo, Cabrera, Silvia, Padrón, José M., Ríos-Luci, Carla, Alvarez-Valdés, Amparo, Navarro-Ranninger, Carmen, Alemán, José
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.2013
Subjects
Biological Assay
Cell Line, Tumor
Cell Proliferation - drug effects
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Drug Screening Assays, Antitumor
Drug Stability
Fluorescence
Fluorescent assays
Humans
Platinum - chemistry
Quinoxalines - chemistry
Quinoxalines - pharmacology
SAR
Structure-Activity Relationship
Sulfanilamides - chemistry
Sulfanilamides - pharmacology
Sulfonamides
Sulfonamides - chemistry
Sulfonamides - pharmacology
Trans-platinum complexes
Trans-platinum complexes
Fluorescent assays
Sulfonamides
SAR
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Abstract In this manuscript, we describe the synthesis of new trans-N-sulfonamide platinum complexes and their antiproliferative activity (GI50, μM) in human solid tumors cells. The structure activity relationships (SAR), with different new synthesized complexes by variation in ligand, halogen and also in the stereochemistry of the ligand, has been studied. Solubility and stability studies have also been carried out as well as fluorescent cell assays in order to clarify the final target in the tumor cells. [Display omitted] ► Synthesis of new trans-platinum complexes containing sulfonamides. ► A structure activity relationship is studied. ► Fluorescent cell assays were studied to clarify the final target in the tumor cells.
AbstractList In this manuscript, we describe the synthesis of new trans-N-sulfonamide platinum complexes and their antiproliferative activity (GI50, μM) in human solid tumors cells. The structure activity relationships (SAR), with different new synthesized complexes by variation in ligand, halogen and also in the stereochemistry of the ligand, has been studied. Solubility and stability studies have also been carried out as well as fluorescent cell assays in order to clarify the final target in the tumor cells.
In this manuscript, we describe the synthesis of new trans-N-sulfonamide platinum complexes and their antiproliferative activity (GI50, μM) in human solid tumors cells. The structure activity relationships (SAR), with different new synthesized complexes by variation in ligand, halogen and also in the stereochemistry of the ligand, has been studied. Solubility and stability studies have also been carried out as well as fluorescent cell assays in order to clarify the final target in the tumor cells. [Display omitted] ► Synthesis of new trans-platinum complexes containing sulfonamides. ► A structure activity relationship is studied. ► Fluorescent cell assays were studied to clarify the final target in the tumor cells.
Author Alvarez-Valdés, Amparo
Quiñones-Lombraña, Adolfo
del Solar, Virginia
Ríos-Luci, Carla
Navarro-Ranninger, Carmen
Alemán, José
Cabrera, Silvia
Padrón, José M.
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Keywords Trans-platinum complexes
Fluorescent assays
Sulfonamides
SAR
Language English
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Snippet In this manuscript, we describe the synthesis of new trans-N-sulfonamide platinum complexes and their antiproliferative activity (GI50, μM) in human solid...
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StartPage 128
SubjectTerms Biological Assay
Cell Line, Tumor
Cell Proliferation - drug effects
Coordination Complexes - chemical synthesis
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
Drug Screening Assays, Antitumor
Drug Stability
Fluorescence
Fluorescent assays
Humans
Platinum - chemistry
Quinoxalines - chemistry
Quinoxalines - pharmacology
SAR
Structure-Activity Relationship
Sulfanilamides - chemistry
Sulfanilamides - pharmacology
Sulfonamides
Sulfonamides - chemistry
Sulfonamides - pharmacology
Trans-platinum complexes
Title Expanding the synthesis of new trans-sulfonamide platinum complexes: Cytotoxicity, SAR, fluorescent cell assays and stability studies
URI https://dx.doi.org/10.1016/j.jinorgbio.2013.01.013
https://www.ncbi.nlm.nih.gov/pubmed/23474039
https://search.proquest.com/docview/1432617372
Volume 127
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