Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction

• Published in: Progress in neurobiology Vol. 219; p. 102369
• Main Authors: Kim, Hyungsup, Kim, Hyesu, Nguyen, Luan Thien, Ha, Taewoong, Lim, Sujin, Kim, Kyungmin, Kim, Soon Ho, Han, Kyungreem, Hyeon, Seung Jae, Ryu, Hoon, Park, Yong Soo, Kim, Sang Hyun, Kim, In-Beom, Hong, Gyu-Sang, Lee, Seung Eun, Choi, Yunsook, Cohen, Lawrence B., Oh, Uhtaek
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2022
• Subjects: Amplification; Animals; Anoctamin 9; Anoctamins - metabolism; cAMP; Cation channel; Mammals - metabolism; Mice; Odorants; Olfaction; Olfactory Bulb - metabolism; Olfactory Receptor Neurons - metabolism; Smell - physiology; TMEM16J; Amplification; Cation channel; TMEM16J; cAMP; Anoctamin 9; Olfaction

Sensing smells of foods, prey, or predators determines animal survival. Olfactory sensory neurons in the olfactory epithelium (OE) detect odorants, where cAMP and Ca2+ play a significant role in transducing odorant inputs to electrical activity. Here we show Anoctamin 9, a cation channel activated b...