Addiction and stress: An allostatic view

• Published in: Neuroscience and biobehavioral reviews Vol. 106; pp. 245 - 262
• Main Authors: Koob, George F., Schulkin, Jay
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.11.2019
• Subjects: Addiction; Allostasis; Corticotropin-releasing factor; Extended amygdala; Glucocorticoids; Stress; Corticotropin-releasing factor; Addiction; Glucocorticoids; Stress; Extended amygdala; Allostasis

•Allostatic stress represents a challenge to emotion-related brain circuit regulatory mechanisms.•Stress alters function in all three stages of the addiction cycle.•Stress contributes to dysregulation of incentive salience/habits, negative emotional states, and executive function.•Stress-induced neu...