Polymorphisms in microRNA binding site of SET8 regulate the risk of rheumatoid arthritis

• Published in: Experimental and therapeutic medicine Vol. 25; no. 6; p. 244
• Main Authors: Peng, Chenxing, Zhao, Yufei, Zhang, Xiaoyun, Zhang, Jingjing, Sha, Ziyue, Zhang, Shasha
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.06.2023; Spandidos Publications UK Ltd; D.A. Spandidos
• Subjects: Antibodies; Binding sites; Binding sites (Biochemistry); Biotechnology; Cell cycle; Cytokines; Development and progression; Disease; Genetic aspects; Genotype & phenotype; Health aspects; Keratin; Laboratories; MicroRNA; MicroRNAs; Oxidative stress; Physiological aspects; Polymorphism; Protein expression; Proteins; Reactive oxygen species; Rheumatoid arthritis; Rheumatology; Risk factors; Single nucleotide polymorphisms; Software; Statistical analysis; Tumor necrosis factor-TNF; China; cytokine; single nucleotide polymorphism; autoimmune disease; reactive oxygen species; genotype

Rheumatoid arthritis (RA) is a complex, heterogeneous, progressive and long-term autoimmune disease characterized by symmetrical joint inflammation and bone erosion. The etiology of RA is unclear, but its pathogenesis is associated with oxidative stress and inflammatory cytokines. Single nucleotide...