In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs’ cleavage by CRISPR/Cas13a system - Chen, Yili; Jiang, Hongye; Wang, Ting; He, Dan; Tian, Rui; Cui, Zifeng; Tian, Xun; Gao, Qinglei; Ma, Xin; Yang, Jianrong; Wu, Jun; Tan, Songwei; et al. (Antiviral research, 2020)
Keywords: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cervical cancer; CRISPR-Cas Systems; CRISPR/Cas13a system; DNA Breaks, Double-Stranded; DNA-Binding Proteins - genetics; Down-Regulation; E6/E7; Female; Genetic Therapy; Growth inhibition; HeLa Cells; HPV 16/18; Human papillomavirus 16 - genetics; Human papillomavirus 18 - genetics; Humans; Mice; Mice, Inbred BALB C; Oncogene Proteins, Viral - genetics; Papillomavirus E7 Proteins - genetics; Papillomavirus Infections - virology; Repressor Proteins - genetics; Retinoblastoma Binding Proteins - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; RNA, Viral - genetics; RNA, Viral - metabolism; Tumor suppression; Tumor Suppressor Protein p53 - genetics; Ubiquitin-Protein Ligases - genetics; Up-Regulation; Uterine Cervical Neoplasms - pathology; Uterine Cervical Neoplasms - virology; Xenograft Model Antitumor Assays; HPV 16/18; Tumor suppression; CRISPR/Cas13a system; Growth inhibition; E6/E7; Cervical cancer