A drug cocktail for protecting against ischemia-reperfusion injury

• Published in: Frontiers in bioscience Vol. 25; no. 4; pp. 722 - 735
• Main Authors: Krzywonos-Zawadzka, Anna, Wozniak, Mieczyslaw, Sawicki, Grzegorz, Bil-Lula, Iwona
• Format: Journal Article
• Language: English
• Published: Singapore IMR Press 01.01.2020
• Subjects: adma; Amidines - pharmacology; Animals; Arginine - analogs & derivatives; Arginine - metabolism; Benzylamines - pharmacology; Enzyme Inhibitors - pharmacology; Heart - drug effects; Heart - physiopathology; inos; ischemia-reperfusion injury; isolated rat hearts; Male; Matrix Metalloproteinase 2 - metabolism; mmp-2; Myocardial Contraction - drug effects; Myocardial Reperfusion Injury - physiopathology; Myocardial Reperfusion Injury - prevention & control; Myocardium - metabolism; Myosin Light Chains - metabolism; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - antagonists & inhibitors; Nitric Oxide Synthase Type II - metabolism; Protective Agents - pharmacology; Rats, Wistar

Ischemia followed by reperfusion (I/R) of cardiomyocytes causes release of a large amount of inducible nitric oxide (NO) synthase (iNOS) followed by an increase of asymmetric dimethylarginine (ADMA). ADMA disrupts NO signaling by switching of the NOS activity from NO to the production of reactive ox...