Quercetin encapsulation in modified silica nanoparticles: potential use against Cu(II)-induced oxidative stress in neurodegeneration

• Published in: Journal of inorganic biochemistry Vol. 145; pp. 51 - 64
• Main Authors: Nday, Christiane M., Halevas, Eleftherios, Jackson, Graham E., Salifoglou, Athanasios
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2015
• Subjects: Animals; Cell Survival - drug effects; Copper - toxicity; Cu(II); Hippocampus - cytology; Hippocampus - drug effects; Microscopy, Electron, Scanning; Modified silica-nanoparticles; Nanoparticles - chemistry; Neurodegeneration; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurodegenerative Diseases - prevention & control; Oxidative stress; Oxidative Stress - drug effects; Quercetin - chemistry; Quercetin - pharmacology; Quercetin encapsulation; Rats; Rats, Sprague-Dawley; Silicon Dioxide - chemistry; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Oxidative stress; Modified silica-nanoparticles; Cu(II); Quercetin encapsulation; Neurodegeneration

Neurodegenerative diseases entail deeply complex processes, intimately associated with progressive brain damage reflecting cellular demise. Biochemical reactivity linked to such processes in Alzheimer’s disease involves, among others, metal-induced oxidative stress contributing to neuronal cell deat...