Cubane Chirality via Substitution of a "Hidden" Regular Tetrahedron

• Published in: Organic letters Vol. 22; no. 11; pp. 4083 - 4087
• Main Authors: Yoshino, Nana, Kato, Yumi, Mabit, Thibaud, Nagata, Yuuya, Williams, Craig M., Harada, Mei, Muranaka, Atsuya, Uchiyama, Masanobu, Matsubara, Seijiro
• Format: Journal Article
• Language: English
• Published: WASHINGTON Amer Chemical Soc 05.06.2020
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; MEDICINAL CHEMISTRY; METALATION; BOND; DISCOVERY

In the hexahedral hydrocarbon cubane, replacing hydrogen with other atoms at three positions within any one of the internal tetrahedrons can conceptually lead to the formation of a unique class of chiral molecules. In pursuit of this endeavor, we prepared 1,3-dibromo-4-deuteriocubane-N,N-diisopropyl...