Urate promotes SNCA/α-synuclein clearance via regulating mTOR-dependent macroautophagy

• Published in: Experimental neurology Vol. 297; pp. 138 - 147
• Main Authors: Sheng, Yu-Lan, Chen, Xing, Hou, Xiao-Ou, Yuan, Xin, Yuan, Bao-Shi, Yuan, Yu-Qing, Zhang, Qi-Lin, Cao, Xian, Liu, Chun-Feng, Luo, Wei-Feng, Hu, Li-Fang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2017
• Subjects: alpha-Synuclein - metabolism; Animals; Autophagy - drug effects; Autophagy - physiology; Cell Survival - drug effects; Cell Survival - physiology; Dose-Response Relationship, Drug; Humans; Macroautophagy; Male; Metabolic Clearance Rate - drug effects; Metabolic Clearance Rate - physiology; Mice; Mice, Inbred C57BL; Mice, Transgenic; mTOR; Parkinson's disease; PC12 Cells; Pilot Projects; Rats; SNCA/α-synuclein; TOR Serine-Threonine Kinases - physiology; Urate; Uric Acid - pharmacology; mTOR; SNCA/α-synuclein; Parkinson's disease; Macroautophagy; Urate

Serum urate levels are reported to be significantly lowered in patients with Parkinson's disease (PD) and inversely correlated to the risk and progression of PD. However, the mechanism by which urate affects PD is poorly understood. Here we showed that treatment with uric acid (UA) resulted in...