Epigenomic and Transcriptomic Characterization of Secondary Breast Cancers

• Published in: Annals of surgical oncology Vol. 25; no. 10; pp. 3082 - 3087
• Main Authors: Graff-Baker, Amanda N., Orozco, Javier I. J., Marzese, Diego M., Salomon, Matthew P., Hoon, Dave S. B., Goldfarb, Melanie
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2018; Springer Nature B.V
• Subjects: Aged; Antigen presentation; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Carcinoma, Ductal, Breast - genetics; Carcinoma, Ductal, Breast - pathology; Carcinoma, Ductal, Breast - surgery; Carcinoma, Lobular - genetics; Carcinoma, Lobular - pathology; Carcinoma, Lobular - surgery; DNA Methylation; DNA sequencing; Epigenomics; Female; Follow-Up Studies; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genome, Human; Genomes; Histocompatibility antigen HLA; Humans; Invasiveness; Malignancy; Medicine; Medicine & Public Health; Middle Aged; Neoplasms, Second Primary - genetics; Neoplasms, Second Primary - pathology; Neoplasms, Second Primary - surgery; Oncology; Patients; Prognosis; Receptor, ErbB-2 - metabolism; Receptors, Estrogen - metabolism; Receptors, Progesterone - metabolism; RelA protein; Ribonucleic acid; RNA; Surgery; Surgical Oncology; Transcriptome; Translational Research and Biomarkers; Tumors; Interferon Response Pathway; The Cancer Genome Atlas (TCGA); Duct Invasion (IDC); Secondary Breast Cancer (SBC); Epigenomic Signatures

Background Molecular alterations impact tumor prognosis and response to treatment. This study was designed to identify transcriptomic and epigenomic signatures of breast cancer (BC) tumors from patients with any prior malignancy. Methods RNA-sequencing and genome-wide DNA methylation profiles from B...