Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway

• Published in: International immunopharmacology Vol. 81; p. 106240
• Main Authors: Yuan, Jiahui, Cheng, Weipeng, Zhang, Gongye, Ma, Qiujuan, Li, Xiaomei, Zhang, Bing, Hu, Tianhui, Song, Gang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2020; Elsevier BV
• Subjects: Animal models; Animals; Anti-Inflammatory Agents - therapeutic use; Cell Line; Colitis; Colitis - chemically induced; Colitis - drug therapy; Colitis, Ulcerative - drug therapy; Colorectal carcinoma; Cornus - immunology; Cytokines; Dextran; Dextran Sulfate; Dextrans; Disease Models, Animal; Glycosides; Glycosides - therapeutic use; Health services; Herbal medicine; Humans; Inflammation; Inflammatory bowel disease; Inflammatory response; Iridoid glycosides; Iridoid Glycosides - therapeutic use; Iridoids - therapeutic use; Lipopolysaccharides; Male; Medical treatment; Medicinal plants; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; NF-kappa B - metabolism; NF-κB protein; Phosphorylation; Signal Transduction; Sodium sulfate; Stat3 protein; STAT3 Transcription Factor - metabolism; STAT3/NF-кB; Traditional Chinese medicine; Inflammatory response; STAT3/NF-кB; Colitis; Iridoid glycosides

•Morroniside and loganin was able to ameliorate intestinal barrier injury and inflammatory reaction in mice models.•The proinflammatory cytokines production was significantly reduced in morroniside and loganin-treated mice.•The possible mechanism of anti-inflammatory response may involve in the bloc...