SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR

• Published in: Viruses Vol. 16; no. 7; p. 1008
• Main Authors: Laprise, Frederique, Arduini, Ariana, Duguay, Mathew, Pan, Qinghua, Liang, Chen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2024
• Subjects: Animals; Cell surface; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 - virology; Down-Regulation; Epithelial cells; Ethylenediaminetetraacetic acid; HEK293 Cells; Homeostasis; Humans; IgA; IgM; Immune Evasion; Immunity, Mucosal; Immunoglobulin A; Immunoglobulin A - immunology; Immunoglobulin M; Infection; Infections; Internalization; Membranes; Mucosal immunity; ORF8; Physiological aspects; pIgR; Plasmids; Proteins; Receptors, Fc; Receptors, Polymeric Immunoglobulin - genetics; Receptors, Polymeric Immunoglobulin - metabolism; Respiratory diseases; SARS-CoV-2; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Viral infections; Viral proteins; Viral Proteins - genetics; Viral Proteins - immunology; Viral Proteins - metabolism; Canada; England; United Kingdom > UK; United States > US; ORF8; pIgR; IgA; SARS-CoV-2; IgM; mucosal immunity

SARS-CoV-2 is a highly pathogenic respiratory virus that successfully initiates and establishes its infection at the respiratory mucosa. However, little is known about how SARS-CoV-2 antagonizes the host's mucosal immunity. Recent findings have shown a marked reduction in the expression of the...