Phosphorylation of the nuclear poly(A) binding protein (PABPN1) during mitosis protects mRNA from hyperadenylation and maintains transcriptome dynamics

• Published in: Nucleic acids research Vol. 52; no. 16; pp. 9886 - 9903
• Main Authors: Gordon, Jackson M, Phizicky, David V, Schärfen, Leonard, Brown, Courtney L, Arias Escayola, Dahyana, Kanyo, Jean, Lam, TuKiet T, Simon, Matthew D, Neugebauer, Karla M
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 09.09.2024
• Subjects: Cell Nucleus - genetics; Cell Nucleus - metabolism; HeLa Cells; Humans; Mitosis - genetics; Phosphorylation; Poly A - metabolism; Poly(A)-Binding Protein I - genetics; Poly(A)-Binding Protein I - metabolism; Polyadenylation; RNA and RNA-protein complexes; RNA Stability - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Transcriptome

Polyadenylation controls mRNA biogenesis, nucleo-cytoplasmic export, translation and decay. These processes are interdependent and coordinately regulated by poly(A)-binding proteins (PABPs), yet how PABPs are themselves regulated is not fully understood. Here, we report the discovery that human nucl...