The potential targets for metastases: a study on altered circular RNA profile in breast cancer liver metastases

To export the expression profile of circRNAs in breast cancer liver metastases (BCLM). RNA sequences were used to identify the altered expression profile of circRNAs in BCLM tissues and 231 liver metastasis cells. Quantitative PCR verified the expression of circRNAs in both BCLM tissues and 231 live...

Full description

Saved in:
Bibliographic Details
Published inEpigenomics Vol. 11; no. 11; pp. 1237 - 1250
Main Authors Lin, Xiaorong, Hong, Shubin, Chen, Jiewen, Chen, Wenying, Wu, Zhiyong
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.08.2019
Subjects
Breast cancer
Cancer therapies
circRNA
circRNA/miRNA network
Circular RNA
epigenetics
expression profile
Gene expression
Gene sequencing
Genes
Hepatocytes
hsa-circ-11783
hsa-circ-21439
Identification methods
Laboratory animals
Liver
Liver cancer
liver metastases
Metastases
Metastasis
miRNA
miRNA sponge
sequencing
United States > US
China
hsa-circ-11783
miRNA sponge
circRNA
breast cancer
circRNA/miRNA network
hsa-circ-21439
epigenetics
expression profile
liver metastases
sequencing
Online AccessGet full text

Cover

Abstract To export the expression profile of circRNAs in breast cancer liver metastases (BCLM). RNA sequences were used to identify the altered expression profile of circRNAs in BCLM tissues and 231 liver metastasis cells. Quantitative PCR verified the expression of circRNAs in both BCLM tissues and 231 liver metastasis cells. The altered expressed circRNAs were found in BCLM tissues, compared with primary tumor tissues. These circRNAs involved in metastatic related signaling pathways. Hsa_circ_21439 and hsa_circ_11783 were verified to be the most significantly up- and downregulated circRNAs in both BCLM tissues and cells. circRNA/miRNA analysis revealed that has_circ_21439 and has_circ_11783 could act as ‘miRNA sponge’. This study provides a potential diagnosis and therapy targets for BCLM.
AbstractList Aim: To export the expression profile of circRNAs in breast cancer liver metastases (BCLM). Materials & methods: RNA sequences were used to identify the altered expression profile of circRNAs in BCLM tissues and 231 liver metastasis cells. Quantitative PCR verified the expression of circRNAs in both BCLM tissues and 231 liver metastasis cells. Results: The altered expressed circRNAs were found in BCLM tissues, compared with primary tumor tissues. These circRNAs involved in metastatic related signaling pathways. Hsa_circ_21439 and hsa_circ_11783 were verified to be the most significantly up- and downregulated circRNAs in both BCLM tissues and cells. In silico circRNA/miRNA analysis revealed that has_circ_21439 and has_circ_11783 could act as ‘miRNA sponge’. Conclusion: This study provides a potential diagnosis and therapy targets for BCLM.
To export the expression profile of circRNAs in breast cancer liver metastases (BCLM). RNA sequences were used to identify the altered expression profile of circRNAs in BCLM tissues and 231 liver metastasis cells. Quantitative PCR verified the expression of circRNAs in both BCLM tissues and 231 liver metastasis cells. The altered expressed circRNAs were found in BCLM tissues, compared with primary tumor tissues. These circRNAs involved in metastatic related signaling pathways. Hsa_circ_21439 and hsa_circ_11783 were verified to be the most significantly up- and downregulated circRNAs in both BCLM tissues and cells. circRNA/miRNA analysis revealed that has_circ_21439 and has_circ_11783 could act as ‘miRNA sponge’. This study provides a potential diagnosis and therapy targets for BCLM.
Aim: To export the expression profile of circRNAs in breast cancer liver metastases (BCLM). Materials & methods: RNA sequences were used to identify the altered expression profile of circRNAs in BCLM tissues and 231 liver metastasis cells. Quantitative PCR verified the expression of circRNAs in both BCLM tissues and 231 liver metastasis cells. Results: The altered expressed circRNAs were found in BCLM tissues, compared with primary tumor tissues. These circRNAs involved in metastatic related signaling pathways. Hsa_circ_21439 and hsa_circ_11783 were verified to be the most significantly up- and downregulated circRNAs in both BCLM tissues and cells. In silico circRNA/miRNA analysis revealed that has_circ_21439 and has_circ_11783 could act as 'miRNA sponge'. Conclusion: This study provides a potential diagnosis and therapy targets for BCLM.Aim: To export the expression profile of circRNAs in breast cancer liver metastases (BCLM). Materials & methods: RNA sequences were used to identify the altered expression profile of circRNAs in BCLM tissues and 231 liver metastasis cells. Quantitative PCR verified the expression of circRNAs in both BCLM tissues and 231 liver metastasis cells. Results: The altered expressed circRNAs were found in BCLM tissues, compared with primary tumor tissues. These circRNAs involved in metastatic related signaling pathways. Hsa_circ_21439 and hsa_circ_11783 were verified to be the most significantly up- and downregulated circRNAs in both BCLM tissues and cells. In silico circRNA/miRNA analysis revealed that has_circ_21439 and has_circ_11783 could act as 'miRNA sponge'. Conclusion: This study provides a potential diagnosis and therapy targets for BCLM.
Author Lin, Xiaorong
Chen, Wenying
Wu, Zhiyong
Chen, Jiewen
Hong, Shubin
AuthorAffiliation 1Diagnosis & Treatment Center of Breast Diseases, Shantou Affiliated Hospital, Sun Yat-sen University, Shantou 515000, Guangdong, PR China
2BreastTumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, PR China
3Department of Endocrinology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510030, PR China
AuthorAffiliation_xml – name: 1Diagnosis & Treatment Center of Breast Diseases, Shantou Affiliated Hospital, Sun Yat-sen University, Shantou 515000, Guangdong, PR China
– name: 2BreastTumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, PR China
– name: 3Department of Endocrinology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510030, PR China
Author_xml – sequence: 1
  givenname: Xiaorong
  surname: Lin
  fullname: Lin, Xiaorong
  organization: Diagnosis & Treatment Center of Breast Diseases, Shantou Affiliated Hospital, Sun Yat-sen University, Shantou515000, Guangdong, PR China, BreastTumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou510120, PR China
– sequence: 2
  givenname: Shubin
  surname: Hong
  fullname: Hong, Shubin
  organization: Department of Endocrinology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou510030, PR China
– sequence: 3
  givenname: Jiewen
  surname: Chen
  fullname: Chen, Jiewen
  organization: BreastTumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou510120, PR China
– sequence: 4
  givenname: Wenying
  surname: Chen
  fullname: Chen, Wenying
  organization: BreastTumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou510120, PR China
– sequence: 5
  givenname: Zhiyong
  orcidid: 0000-0003-2535-1619
  surname: Wu
  fullname: Wu, Zhiyong
  organization: Diagnosis & Treatment Center of Breast Diseases, Shantou Affiliated Hospital, Sun Yat-sen University, Shantou515000, Guangdong, PR China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31293174$$D View this record in MEDLINE/PubMed
BookMark eNp1kc1rFTEUxYNUbK1dupWAGzejuUleMnFXil9QFKSCu5Bk7mjKvOSZZIT-9-b5WpFCQyA38DuHwz1PyVHKCQl5Duw156Df4C4OnIEZGDPmETkBvWEDGP796N8McEzOar1m_Qg-GgVPyLEAbgRoeULy1U-ku9wwtegW2lz5ga3SORe6xeZqv1jfUkdrW6cbmhN1S8OCEw2xhHVxhX79fE53Jc9xQRoT9QW7jAaXAha6xN_4v9Uz8nh2S8Wz2_eUfHv_7uri43D55cOni_PLIQgNbeCgjPBjCHIew-iYZxCk0sZ7FbzQYfRs1sCFA4Bg9DRyrpyc9aQ2YpTOi1Py6uDbk_1asTa7jTXgsriEea2W841iZmRMdfTlPfQ6ryX1dJYLqaTcyL_Ui1tq9Vuc7K7ErSs39m6VHRAHIJRca8HZhthcizm14uJigdl9Z7Z3Zved2X1nXTXcU90ZP8SbAz-vbS1YQ8S-Z3v49VwxxIQPaP8Ac2WrTw
CitedBy_id crossref_primary_10_1186_s12957_021_02332_0
crossref_primary_10_1038_s41572_021_00261_6
crossref_primary_10_1016_j_prp_2024_155569
crossref_primary_10_3389_fonc_2021_691317
crossref_primary_10_1080_21655979_2021_2006552
crossref_primary_10_3389_fcell_2021_647736
Cites_doi 10.1186/s12967-015-0425-0
10.1016/j.pharmthera.2018.01.010
10.1038/nature11993
10.1016/S1470-2045(09)70029-4
10.3892/or.2015.3873
10.1038/nature06487
10.1016/j.canlet.2014.03.018
10.3322/caac.21442
10.1016/j.canlet.2018.01.011
10.1056/NEJMoa0901282
10.1158/0008-5472.CAN-10-1850
10.3892/or.2016.4617
10.1016/j.febslet.2011.04.018
10.1038/nature11928
10.1186/s12943-018-0771-7
10.1152/ajplung.00163.2007
10.1016/j.breast.2013.04.017
10.1016/S0003-4975(03)00149-8
10.1007/s10147-011-0336-x
10.1371/journal.pone.0016264
10.1016/j.cell.2007.03.047
10.1002/ijc.31898
ContentType Journal Article
Copyright 2019 Future Medicine Ltd
Copyright Future Medicine Ltd Aug 2019
Copyright_xml – notice: 2019 Future Medicine Ltd
– notice: Copyright Future Medicine Ltd Aug 2019
DBID AAYXX
CITATION
NPM
3V.
7X7
7XB
88E
8AO
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
CCPQU
DWQXO
EHMNL
FYUFA
GHDGH
GNUQQ
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
7X8
DOI 10.2217/epi-2019-0099
DatabaseName CrossRef
PubMed
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection (ProQuest)
ProQuest One Community College
ProQuest Central Korea
UK & Ireland Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
ProQuest advanced technologies & aerospace journals
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
DatabaseTitle CrossRef
PubMed
ProQuest Central Student
Technology Collection
ProQuest One Academic Middle East (New)
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
ProQuest Health & Medical Research Collection
Health Research Premium Collection
Health and Medicine Complete (Alumni Edition)
Natural Science Collection
ProQuest Central Korea
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest SciTech Collection
ProQuest Hospital Collection (Alumni)
Advanced Technologies & Aerospace Database
ProQuest Health & Medical Complete
ProQuest Medical Library
UK & Ireland Database
ProQuest One Academic UKI Edition
ProQuest One Academic
ProQuest One Academic (New)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList ProQuest Central Student

PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Languages & Literatures
Zoology
EISSN 1750-192X
EndPage 1250
ExternalDocumentID 31293174
10_2217_epi_2019_0099
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations United States--US
China
GeographicLocations_xml – name: China
– name: United States--US
GroupedDBID -
0R
3V.
53G
70G
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
ABUWG
ACGFS
ACPRK
ADBBV
AENEX
AFKRA
AHMBA
ALMA_UNASSIGNED_HOLDINGS
ARAPS
BBAFP
BBNVY
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
DU5
EBS
EHMNL
EJD
F5P
FYUFA
HCIFZ
HZ
IAO
IEA
IHR
LK8
M1P
M7P
MV1
NTCAX
O9-
P62
PQEST
PQQKQ
PRINS
PROAC
PSQYO
RFM
---
0R~
4.4
AAWFG
AAYXX
ABJNI
ACWKX
AFFYO
ALIPV
CCPQU
CITATION
H13
HMCUK
HZ~
ITC
M4Z
OVD
PHGZM
PHGZT
RPM
TDBHL
TEORI
TFL
TFMDE
TMEDX
UKHRP
NPM
7XB
8FK
ABNDM
AZQEC
DWQXO
GNUQQ
K9.
PJZUB
PKEHL
PPXIY
PQGLB
PQUKI
7X8
ID FETCH-LOGICAL-c371t-21693b8cc4f8c8a0b01c4679bb6cb37c8b0f7123a111c97d8226a4f7d65384ab3
IEDL.DBID 7X7
ISSN 1750-1911
1750-192X
IngestDate Thu Jul 10 23:57:21 EDT 2025
Fri Jul 25 18:50:26 EDT 2025
Thu Jan 02 22:58:13 EST 2025
Thu Apr 24 22:52:44 EDT 2025
Tue Jul 01 02:14:42 EDT 2025
Tue Jan 05 21:45:22 EST 2021
IsPeerReviewed true
IsScholarly true
Issue 11
Keywords hsa-circ-11783
miRNA sponge
circRNA
breast cancer
circRNA/miRNA network
hsa-circ-21439
epigenetics
expression profile
liver metastases
sequencing
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c371t-21693b8cc4f8c8a0b01c4679bb6cb37c8b0f7123a111c97d8226a4f7d65384ab3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Case Study-2
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ORCID 0000-0003-2535-1619
PMID 31293174
PQID 2346445406
PQPubID 135346
PageCount 14
ParticipantIDs proquest_miscellaneous_2256098006
proquest_journals_2346445406
pubmed_primary_31293174
crossref_citationtrail_10_2217_epi_2019_0099
crossref_primary_10_2217_epi_2019_0099
futurescience_futuremedicine_10_2217_epi_2019_0099
ProviderPackageCode RFM
NTCAX
70G
CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-08-01
PublicationDateYYYYMMDD 2019-08-01
PublicationDate_xml – month: 08
  year: 2019
  text: 2019-08-01
  day: 01
PublicationDecade 2010
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Epigenomics
PublicationTitleAlternate Epigenomics
PublicationYear 2019
Publisher Future Medicine Ltd
Publisher_xml – name: Future Medicine Ltd
References e_1_3_4_4_1
e_1_3_4_3_1
e_1_3_4_9_1
e_1_3_4_8_1
e_1_3_4_7_1
e_1_3_4_20_1
e_1_3_4_6_1
e_1_3_4_5_1
e_1_3_4_12_1
e_1_3_4_23_1
e_1_3_4_13_1
e_1_3_4_24_1
e_1_3_4_10_1
e_1_3_4_21_1
e_1_3_4_11_1
e_1_3_4_22_1
e_1_3_4_16_1
e_1_3_4_17_1
e_1_3_4_14_1
e_1_3_4_15_1
e_1_3_4_18_1
e_1_3_4_19_1
References_xml – ident: e_1_3_4_8_1
  doi: 10.1186/s12967-015-0425-0
– ident: e_1_3_4_12_1
  doi: 10.1016/j.pharmthera.2018.01.010
– ident: e_1_3_4_13_1
  doi: 10.1038/nature11993
– ident: e_1_3_4_7_1
  doi: 10.1016/S1470-2045(09)70029-4
– ident: e_1_3_4_10_1
  doi: 10.3892/or.2015.3873
– ident: e_1_3_4_20_1
  doi: 10.1038/nature06487
– ident: e_1_3_4_23_1
  doi: 10.1016/j.canlet.2014.03.018
– ident: e_1_3_4_3_1
  doi: 10.3322/caac.21442
– ident: e_1_3_4_11_1
  doi: 10.1016/j.canlet.2018.01.011
– ident: e_1_3_4_16_1
  doi: 10.1056/NEJMoa0901282
– ident: e_1_3_4_18_1
  doi: 10.1158/0008-5472.CAN-10-1850
– ident: e_1_3_4_21_1
  doi: 10.3892/or.2016.4617
– ident: e_1_3_4_17_1
  doi: 10.1016/j.febslet.2011.04.018
– ident: e_1_3_4_15_1
  doi: 10.1038/nature11928
– ident: e_1_3_4_14_1
  doi: 10.1186/s12943-018-0771-7
– ident: e_1_3_4_22_1
  doi: 10.1152/ajplung.00163.2007
– ident: e_1_3_4_4_1
  doi: 10.1016/j.breast.2013.04.017
– ident: e_1_3_4_5_1
  doi: 10.1016/S0003-4975(03)00149-8
– ident: e_1_3_4_6_1
  doi: 10.1007/s10147-011-0336-x
– ident: e_1_3_4_19_1
  doi: 10.1371/journal.pone.0016264
– ident: e_1_3_4_24_1
  doi: 10.1016/j.cell.2007.03.047
– ident: e_1_3_4_9_1
  doi: 10.1002/ijc.31898
SSID ssj0000328961
Score 2.2225027
Snippet To export the expression profile of circRNAs in breast cancer liver metastases (BCLM). RNA sequences were used to identify the altered expression profile of...
Aim: To export the expression profile of circRNAs in breast cancer liver metastases (BCLM). Materials & methods: RNA sequences were used to identify the...
SourceID proquest
pubmed
crossref
futurescience
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1237
SubjectTerms Breast cancer
Cancer therapies
circRNA
circRNA/miRNA network
Circular RNA
epigenetics
expression profile
Gene expression
Gene sequencing
Genes
Hepatocytes
hsa-circ-11783
hsa-circ-21439
Identification methods
Laboratory animals
Liver
Liver cancer
liver metastases
Metastases
Metastasis
miRNA
miRNA sponge
sequencing
Title The potential targets for metastases: a study on altered circular RNA profile in breast cancer liver metastases
URI http://dx.doi.org/10.2217/epi-2019-0099
https://www.ncbi.nlm.nih.gov/pubmed/31293174
https://www.proquest.com/docview/2346445406
https://www.proquest.com/docview/2256098006
Volume 11
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Ra9RAEB60RRBEtGo9bcsI0idD77J7u4kv0paeReohxcLhS9jdbOCgJucl_f_OZPdSfbi-BEI2S8hMZr6d_fINwEet9dRmzPMTlU6kMTLhviJJOZVO-Gnmx5YL-t_n6vJGfltMF7Hg1kZa5SYm9oG6bBzXyE9SISl1E75QX1Z_Eu4axbursYXGY9hl6TL2ar3QQ42FteLyIJlKiTGhpckkyGymBMRP_GpJPsL_8Ix75df7tPQs6HnEHLQde_Y5aPYCnkfwiKfB2i_hka_3YP8qlhxbPMarQSW53YMnv5q-aP4KGvIGXDUdU4NogkD_bpEAK_72nSGE2Pr2Mxrs1WaxqbHfRfcluuW6Z6ri9fwUY4NvXNZomczeoWOnWeMtszv-meo13Mwufp5fJrHVQuKEnnRJyposNnNOVpnLDFdHHYXQ3FrlrNAus-NKU5IzFBpdrkuCFcrISpeKAqY0VryBnbqp_VtAYVXuc6G8YmX9NLdaOoJptDQxWuXVZASfNm-6cFGHnNth3Ba0HmHDFGSYgg1TsGFGcDwMXwUBjm0D0__MVoSzDUVh200HG9sW8eNti3tXG8GH4TJ9dryXYmrf3NEYhoo5oW0asx98Yng8wRiKVnrvHp78PTwN7sdswgPY6dZ3_pAQTmePejemYzb7egS7ZxfzH9d_Aa9s-rI
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Rb9MwED6NIQTShGDAKAw4JNgT0drYjRMkhCagdKzrA9qkiZdgO45UaSRdkwnxp_iN3MVJBg_lbY9VHavqfbn77nz-DuCVUmpsYu7zE7kKpNYy4LkiQTaWVrhx7IaGC_rH82h6Kr-cjc824Hd3F4bbKjuf2DjqrLRcI98PhaTQTfwier-8CHhqFJ-udiM0PCyO3K-flLJV7w4_kn1fh-Hk08mHadBOFQisUKM6CFl-xMTWyjy2seZCoCVvkRgTWSOUjc0wV-TPNXkBm6iMImikZa6yiHyD1EbQvjfgphQUyflm-uRzX9NhbbrES7RSIA4oFRp5Wc-QiP--Wy4Ik3xnaNgozV6FwS2vH9LGvPVct4l5k3twtyWreODRdR82XLENO7O2xFnhHs56VeZqG259K5si_QMoCX24LGtuRaINfLt5hUSQ8YerNTHSylVvUWOjbotlgc2pvcvQLlZNZyx-nR9gO1AcFwUabp6v0TJIV3jO3SR_bfUQTq_FCI9gsygL9xhQmChxiYhcxEr-YWKUtEQLKRXSKkry0QDedP90alvdcx6_cZ5S_sOGSckwKRsmZcMMYK9fvvSCH-sWhv-YLfWfupaIdQ_tdrZNW2dRpVfQHsDL_mt6zfnsRheuvKQ1TE0TYve0Zsdjov95gjkbZZZP_r_5C7g9PTmepbPD-dFTuOOhyJ2Mu7BZry7dM2JXtXneQBrh-3W_Q38AFs80dQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Ra9RAEB7qFUWQolXr2aojaJ8Md5fksklBpNoerT2PUiwUX9bdzQYOanJeUsS_5q_rTDZJ9eF86-Nxm-W4mZ35ZvbLNwBvhBBjHTPPL8iEFyoVejxXxEvHoQnsOLZDzQ39L7Po6Dz8fDG-WIM_7bswTKtsY2IdqNPCcI984AchpW7CF9Ega2gRpweTD4ufHk-Q4pvWdpyGc5ET-_sXlW_l--MDsvVb358cfv105DUTBjwTiFHl-SxFomNjwiw2seKmoKHIkWgdGR0IE-thJii2K4oIJhEpZdNIhZlII4oTodIB7XsH1gVXRT1Y_3g4Oz3rOjysVJc4wVZKyx4VRiMn8ulTGTCwizl5KL9BNKx1Z2-S4gOnJtJkwNXIt86Ak4ew0UBX3He-9gjWbL4JW9Om4VniLk47jeZyE-5-K-qW_WMoyBdxUVRMTKINHPm8RILL-MNWivBpacs9VFhr3WKRY32Hb1M082XNk8Wz2T4248VxnqNmKn2Fhl12iZfMLflrqydwfitmeAq9vMjtM8BAR4lNgshGrOvvJ1qEhkAiFUZKREk26sO79p-WplFB52Ecl5KqITaMJMNINoxkw_Rht1u-cPIfqxb6_5hNuk8tQWLVQzutbWUTOkp54-h9eN19TYeeb3JUbosrWsNANSGsT2u2nE90Py9gBEd15vP_b_4K7tH5kdPj2ck23HeeyLTGHehVyyv7gqBWpV82Po3w_baP0TWrcjoH
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+potential+targets+for+metastases%3A+a+study+on+altered+circular+RNA+profile+in+breast+cancer+liver+metastases&rft.jtitle=Epigenomics&rft.au=Lin%2C+Xiaorong&rft.au=Shubin%2C+Hong&rft.au=Chen%2C+Jiewen&rft.au=Chen%2C+Wenying&rft.date=2019-08-01&rft.pub=Future+Medicine+Ltd&rft.issn=1750-1911&rft.eissn=1750-192X&rft.volume=11&rft.issue=11&rft.spage=1237&rft_id=info:doi/10.2217%2Fepi-2019-0099&rft.externalDBID=HAS_PDF_LINK
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1750-1911&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1750-1911&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1750-1911&client=summon