A family cluster of cutaneous Leishmania major infection unresponsive to intralesional meglumine antimonial: Case reports

We describe a family cluster of L. major that became infected by traveling to an endemic focus of CL, which did not respond to intralesional meglumine antimonial treatment whilst two were hospitalized due to the progressive disease that responded to 4 weeks of oral ketoconazole. Parasite genotyping...

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Bibliographic Details
Published inIndian journal of medical microbiology Vol. 40; no. 3; pp. 451 - 454
Main Authors Ziaee, Masood, Ghatee, Mohammad Amin, Taylor, Walter Robert, Karamian, Mehdi
Format Journal Article
LanguageEnglish
Published United States Elsevier B.V 01.07.2022
Subjects
DNA sequencing
Ketoconazole
Leishmania major
Ketoconazole
Leishmania major
DNA sequencing
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Summary:We describe a family cluster of L. major that became infected by traveling to an endemic focus of CL, which did not respond to intralesional meglumine antimonial treatment whilst two were hospitalized due to the progressive disease that responded to 4 weeks of oral ketoconazole. Parasite genotyping of the internal transcribed spacer 1 gene revealed the same infecting parasite strain in all family members and was the same strain in GenBank that caused mucosal L. major in a tourist who visited several North African countries. We hypothesise a reduced host immune response in the two hospitalized patients.
ISSN:0255-0857
1998-3646
DOI:10.1016/j.ijmmb.2022.05.008