Targeting T-bet expressing B cells for therapeutic interventions in autoimmunity

• Published in: Clinical and experimental immunology Vol. 217; no. 2; pp. 159 - 166
• Main Authors: Sachinidis, Athanasios, Lamprinou, Malamatenia, Dimitroulas, Theodoros, Garyfallos, Alexandros
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 12.07.2024
• Subjects: Animals; Autoimmune Diseases - immunology; Autoimmune Diseases - therapy; Autoimmunity - immunology; Autoimmunity/Autoimmune Disease; B-Lymphocytes - immunology; Disease Models, Animal; Humans; Lupus Erythematosus, Systemic - immunology; Lupus Erythematosus, Systemic - therapy; Mice; T-bet Transcription Factor; T-Box Domain Proteins - genetics; T-Box Domain Proteins - immunology; T-Box Domain Proteins - metabolism; autoimmunity; double-negative B cells; T-bet; age-associated B cells

Summary Apart from serving as a Th1 lineage commitment regulator, transcription factor T-bet is also expressed in other immune cell types and thus orchestrates their functions. In case of B cells, more specifically, T-bet is responsible for their isotype switching to specific IgG sub-classes (IgG2a/...