Pneumothorax during lenvatinib treatment for hepatocellular carcinoma with lung metastasis

Lenvatinib is an inhibitor of tyrosine kinases, such as vascular endothelial growth factor receptor and fibroblast growth factor receptor, and was first approved for use in thyroid cancer in 2015 in Japan. Additional approval was given in March 2018 for its use as a first-line treatment for advanced...

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Published inClinical journal of gastroenterology Vol. 14; no. 1; pp. 288 - 292
Main Authors Kawanishi, Yasuhiro, Kuwahara, Michio, Utsunomiya, Masato, Ishida, Nobuko, Ishikawa, Yoichi, Hiroi, Makoto, Akimori, Toyokazu
Format Journal Article
LanguageEnglish
Published Singapore Springer Singapore 01.02.2021
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Abstract Lenvatinib is an inhibitor of tyrosine kinases, such as vascular endothelial growth factor receptor and fibroblast growth factor receptor, and was first approved for use in thyroid cancer in 2015 in Japan. Additional approval was given in March 2018 for its use as a first-line treatment for advanced or unresectable hepatocellular carcinoma. Herein, we report a case of pneumothorax during lenvatinib treatment for multiple lung metastases of hepatocellular carcinoma in a 71-year-old man. Although the development of pneumothorax during treatment with anticancer agents for lung metastases is well-known, this is the first report of pneumothorax induced by lenvatinib during treatment for lung metastases of hepatocellular carcinoma.
AbstractList Lenvatinib is an inhibitor of tyrosine kinases, such as vascular endothelial growth factor receptor and fibroblast growth factor receptor, and was first approved for use in thyroid cancer in 2015 in Japan. Additional approval was given in March 2018 for its use as a first-line treatment for advanced or unresectable hepatocellular carcinoma. Herein, we report a case of pneumothorax during lenvatinib treatment for multiple lung metastases of hepatocellular carcinoma in a 71-year-old man. Although the development of pneumothorax during treatment with anticancer agents for lung metastases is well-known, this is the first report of pneumothorax induced by lenvatinib during treatment for lung metastases of hepatocellular carcinoma.
Author Ishikawa, Yoichi
Utsunomiya, Masato
Hiroi, Makoto
Kawanishi, Yasuhiro
Ishida, Nobuko
Akimori, Toyokazu
Kuwahara, Michio
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  surname: Akimori
  fullname: Akimori, Toyokazu
  organization: Department of Surgery, Kochi Prefectural Hata Kenmin Hospital
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Cites_doi 10.2995/jacsurg.27.611
10.2169/internalmedicine.55.7155
10.1089/thy.2017.0205
10.1093/jjco/hyq195
10.1155/2018/7875929
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Keywords Hepatocellular carcinoma
Pneumothorax
Lenvatinib
Lung metastasis
Language English
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Snippet Lenvatinib is an inhibitor of tyrosine kinases, such as vascular endothelial growth factor receptor and fibroblast growth factor receptor, and was first...
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SubjectTerms Abdominal Surgery
Case Report
Colorectal Surgery
Gastroenterology
Hepatology
Medicine
Medicine & Public Health
Surgical Oncology
Title Pneumothorax during lenvatinib treatment for hepatocellular carcinoma with lung metastasis
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