Co-expression of HBZ, TAX and FOXp3 and HTLV-1-associated myelopathy/ tropical spastic paraparesis development in HTLV-1-infected individuals: A systematic review

• Published in: Asian Pacific journal of tropical medicine Vol. 14; no. 8; pp. 333 - 340
• Main Authors: Lima, Ana, da Silva, Greice, Barreto, Fernanda, Rego, Filipe, Gois, Luana, Santos, Luciane
• Format: Journal Article
• Language: English
• Published: Wolters Kluwer India Pvt. Ltd 01.08.2021; Wolters Kluwer Medknow Publications
• Subjects: htlv-1; htlv-1-associated myelopathy/tropical spastic paraparesis (ham/tsp); foxp3; hbz; tax

Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been reported that the HTLV-1 proteins (specifically TAX and HBZ) can modulate FOXp3, resulting in an immune imbalance that can favor the...