Co-expression of HBZ, TAX and FOXp3 and HTLV-1-associated myelopathy/ tropical spastic paraparesis development in HTLV-1-infected individuals: A systematic review
Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been reported that the HTLV-1 proteins (specifically TAX and HBZ) can modulate FOXp3, resulting in an immune imbalance that can favor the...
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| Published in | Asian Pacific journal of tropical medicine Vol. 14; no. 8; pp. 333 - 340 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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Wolters Kluwer India Pvt. Ltd
01.08.2021
Wolters Kluwer Medknow Publications |
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| Abstract | Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been reported that the HTLV-1 proteins (specifically TAX and HBZ) can modulate FOXp3, resulting in an immune imbalance that can favor the progression of HAM/TSP. This review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 mRNAs and/or viral proteins (TAX and HBZ) with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/ TSP development. This systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. The search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject descriptors. After screening, six articles were included in this review. The studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP, which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy donors. This systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/ TSP development. |
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| AbstractList | Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). It has been reported that the HTLV-1 proteins (specifically TAX and HBZ) can modulate FOXp3, resulting in an immune imbalance that can favor the progression of HAM/TSP. This review aims to summarize the literature in order to clarify the relationship between the expression of HTLV-1 mRNAs and/or viral proteins (TAX and HBZ) with the expression of mRNA and/or protein FOXp3 and their correlation with HAM/ TSP development. This systematic review was conducted according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. The search strategy was performed on the Medical Literature Analysis and Retrieval System Online and Latin American and Caribbean Literature in Health Sciences Platform using subject descriptors. After screening, six articles were included in this review. The studies suggested that TAX and HBZ have a directly proportional correlation with FOXp3 in individuals with HAM/TSP, which also presented an increased expression of FOXp3 compared to asymptomatic controls and/or healthy donors. This systematic review indicates that TAX and HBZ can interact with FOXp3 and that interaction may influence HAM/ TSP development. |
| Author | Santos, Luciane da Silva, Greice Lima, Ana Gois, Luana Barreto, Fernanda Rego, Filipe |
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| Cites_doi | 10.1016/j.pharmthera.2020.107669 10.3389/fmicb.2012.00389 10.1086/503874 10.1186/s12885-018-5209-5 10.3389/fmicb.2012.00388 10.1016/S0166-0934(02)00097-6 10.1016/j.jns.2005.05.010 10.1146/annurev-immunol-042718-041717 10.1371/journal.pntd.0006967 10.1186/s12977-020-0511-0 10.1182/blood-2007-11-123430 10.1073/pnas.77.12.7415 10.1186/s12977-019-0483-0 10.14712/18059694.2016.63 10.1016/j.jdermsci.2009.02.001 10.1089/aid.1992.8.1699 10.1016/j.cell.2006.05.042 10.1084/jem.20032042 10.1128/JVI.73.6.4575-4581.1999 10.1371/journal.ppat.1003630 10.1186/s13023-020-01451-3 10.1182/blood.V99.1.88 10.1371/journal.ppat.1001274 10.3390/v10120691 10.1101/gr.9.6.525 10.1186/1742-4690-2-75 10.1182/blood-2007-10-118539 10.1038/sj.onc.1208968 10.1172/JCI23913 10.1007/s11481-014-9547-z 10.1186/1742-4690-9-46 10.1089/aid.2013.0109 10.1002/jcb.26546 10.1182/blood-2010-12-326199 10.1182/blood.V98.3.721 10.1371/journal.pmed.1000097 10.1084/jem.20030152 10.1002/jcb.240460405 10.1093/cid/civ229 10.1007/s10875-019-00684-7 10.1007/s13365-015-0407-2 10.1016/j.bjid.2015.07.008 10.1590/S0100-879X2010007500107 10.3109/13550289809114225 |
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| References | Yamakawa (R8-1-20240830) 2020; 15 Yamamoto-Taguchi (R26-1-20240830) 2013; 9 Grant (R45-1-20240830) 2008; 111 Chen (R40-1-20240830) 2003; 198 Pecon Slattery (R3-1-20240830) 1999; 9 Nozuma (R13-1-20240830) 2020; 26 Kondělková (R43-1-20240830) 2010; 53 Matsuoka (R17-1-20240830) 2020; 17 Asquith (R35-1-20240830) 2005; 2 Makino (R38-1-20240830) 1999; 73 Satou (R41-1-20240830) 2011; 7 Eusebio-Ponce (R5-1-20240830) 2019; 32 Yasuma (R23-1-20240830) 2016; 22 Moher (R18-1-20240830) 2009; 6 Gessain (R2-1-20240830) 2012; 3 Yamano (R16-1-20240830) 2005; 115 Tanajura (R10-1-20240830) 2015; 61 Hanon (R31-1-20240830) 2001; 98 Sakaguchi (R28-1-20240830) 2020; 38 Nagai (R33-1-20240830) 1998; 4 Pinto (R22-1-20240830) 2014; 30 Kaplan (R6-1-20240830) 1990; 3 Haziot (R9-1-20240830) 2019; 13 Wu (R29-1-20240830) 2006; 126 Yamano (R36-1-20240830) 2004; 199 Zhao (R25-1-20240830) 2011; 118 Yamauchi (R47-1-20240830) 2021; 218 Olindo (R34-1-20240830) 2005; 237 Anderson (R27-1-20240830) 2014; 9 Oh (R19-1-20240830) 2006; 193 Tarokhian (R24-1-20240830) 2018; 18 Yamazaki (R39-1-20240830) 2009; 54 Yamano (R15-1-20240830) 2002; 99 Toulza (R21-1-20240830) 2008; 111 Futsch (R46-1-20240830) 2018; 10 Yamano (R7-1-20240830) 2012; 3 Ramirez (R20-1-20240830) 2010; 43 Satou (R30-1-20240830) 2012; 9 Macatonia (R37-1-20240830) 1992; 8 Poiesz (R1-1-20240830) 1980; 77 Tendler (R44-1-20240830) 1991; 46 Royer-Leveau (R32-1-20240830) 2002; 105 Proietti (R4-1-20240830) 2005; 24 Georgiev (R14-1-20240830) 2019; 39 Pinto (R42-1-20240830) 2015; 19 Mozhgani (R11-1-20240830) 2018; 119 Martinez (R12-1-20240830) 2019; 16 |
| References_xml | – volume: 218 start-page: 107669 year: 2021 ident: R47-1-20240830 article-title: An update on human T-cell leukemia virus type I (HTLV-1)-associated myelopathy/ tropical spastic paraparesis (HAM/TSP) focusing on clinical and laboratory biomarkers publication-title: Pharmacol Therapeut doi: 10.1016/j.pharmthera.2020.107669 – volume: 3 start-page: 389 year: 2012 ident: R7-1-20240830 article-title: Clinical pathophysiology of human T-lymphotropic virus-type 1-associated myelopathy/tropical spastic paraparesis publication-title: Front Microbiol doi: 10.3389/fmicb.2012.00389 – volume: 193 start-page: 1557 year: 2006 ident: R19-1-20240830 article-title: Reduced Foxp3 protein expression is associated with inflammatory disease during human T lymphotropic virus type 1 infection publication-title: J Infect Dis doi: 10.1086/503874 – volume: 18 start-page: 1287 year: 2018 ident: R24-1-20240830 article-title: HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: Virus and host gene expressions publication-title: BMC Cancer doi: 10.1186/s12885-018-5209-5 – volume: 3 start-page: 388 year: 2012 ident: R2-1-20240830 article-title: Epidemiological aspects and world distribution of HTLV-1 infection publication-title: Front Microbiol doi: 10.3389/fmicb.2012.00388 – volume: 105 start-page: 133 year: 2002 ident: R32-1-20240830 article-title: Efficient transfer of HTLV-1 tax gene in various primary and immortalized cells using a flap lentiviral vector publication-title: J Virol Method doi: 10.1016/S0166-0934(02)00097-6 – volume: 237 start-page: 53 year: 2005 ident: R34-1-20240830 article-title: HTLV-1 proviral load in peripheral blood mononuclear cells quantified in 100 HAM/TSP patients: A marker of disease progression publication-title: J Neurol Sci doi: 10.1016/j.jns.2005.05.010 – volume: 38 start-page: 541 year: 2020 ident: R28-1-20240830 article-title: Regulatory T cells and human disease publication-title: Ann Rev Immunol doi: 10.1146/annurev-immunol-042718-041717 – volume: 13 start-page: e0006967 year: 2019 ident: R9-1-20240830 article-title: Detection of clinical and neurological signs in apparently asymptomatic HTLV-1 infected carriers: Association with high proviral load publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0006967 – volume: 17 start-page: 1 year: 2020 ident: R17-1-20240830 article-title: HTLV-1 bZIP factor: The key viral gene for pathogenesis publication-title: Retrovirology doi: 10.1186/s12977-020-0511-0 – volume: 111 start-page: 5601 year: 2008 ident: R45-1-20240830 article-title: Dysregulation of TGF-β signaling and regulatory and effector T-cell function in virus-induced neuroinflammatory disease publication-title: Blood doi: 10.1182/blood-2007-11-123430 – volume: 77 start-page: 7415 year: 1980 ident: R1-1-20240830 article-title: Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.77.12.7415 – volume: 16 start-page: 21 year: 2019 ident: R12-1-20240830 article-title: Comparative virology of HTLV-1 and HTLV-2 publication-title: Retrovirology doi: 10.1186/s12977-019-0483-0 – volume: 53 start-page: 73 year: 2010 ident: R43-1-20240830 article-title: Regulatory T cells (TREG) and their roles in immune system with respect to immunopathological disorders publication-title: Acta Medica (Hradec Kralove doi: 10.14712/18059694.2016.63 – volume: 54 start-page: 69 year: 2009 ident: R39-1-20240830 article-title: Dendritic cells as controllers of antigen-specific Foxp3+ regulatory T cells publication-title: J Dermatol Sci doi: 10.1016/j.jdermsci.2009.02.001 – volume: 8 start-page: 1699 year: 1992 ident: R37-1-20240830 article-title: Dendritic cells from patients with tropical spastic paraparesis are infected with HTLV-1 and stimulate autologous lymphocyte proliferation publication-title: AIDS Res Hum Retroviruses doi: 10.1089/aid.1992.8.1699 – volume: 3 start-page: 1096 year: 1990 ident: R6-1-20240830 article-title: The risk of development of htlv-i-associated myelopathy/tropical spastic paraparesis among persons infected with htlv-i publication-title: J Acquir Immune Defic Syndr – volume: 126 start-page: 375 year: 2006 ident: R29-1-20240830 article-title: FOXP3 controls regulatory t cell function through cooperation with NFAT publication-title: Cell doi: 10.1016/j.cell.2006.05.042 – volume: 199 start-page: 1367 year: 2004 ident: R36-1-20240830 article-title: Increased expression of human T lymphocyte virus type I (HTLV-I) Tax11-19 peptide-human histocompatibility leukocyte antigen A*201 complexes on CD4+CD25+ T cells detected by peptide-specific, major histocompatibility complex-restricted antibodies in patients with HTLV-I-associated neurologic disease publication-title: J Exp Med doi: 10.1084/jem.20032042 – volume: 73 start-page: 4575 year: 1999 ident: R38-1-20240830 article-title: The role of human T-lymphotropic virus type 1 (HTLV-1)-infected dendritic cells in the development of HTLV-1-associated myelopathy/tropical spastic paraparesis publication-title: J Virol doi: 10.1128/JVI.73.6.4575-4581.1999 – volume: 9 start-page: 1 year: 2013 ident: R26-1-20240830 article-title: HTLV-1 bZIP factor induces inflammation through labile foxp3 expression publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1003630 – volume: 15 start-page: 175 year: 2020 ident: R8-1-20240830 article-title: Creation and validation of a bladder dysfunction symptom score for HTLV-1-associated myelopathy/tropical spastic paraparesis publication-title: Orphanet J Rare Dis doi: 10.1186/s13023-020-01451-3 – volume: 99 start-page: 88 year: 2002 ident: R15-1-20240830 article-title: Correlation of human T-cell lymphotropic virus type 1 (HTLV-1) mRNA with proviral DNA load, virus-specific CD8+ T cells, and disease severity in HTLV-1-associated myelopathy (HAM/TSP) publication-title: Blood doi: 10.1182/blood.V99.1.88 – volume: 7 start-page: e1001274 year: 2011 ident: R41-1-20240830 article-title: HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo publication-title: PLoS Pathog doi: 10.1371/journal.ppat.1001274 – volume: 10 start-page: 691 year: 2018 ident: R46-1-20240830 article-title: Cytokine networks dysregulation during htlv-1 infection and associated diseases publication-title: Viruses doi: 10.3390/v10120691 – volume: 9 start-page: 525 year: 1999 ident: R3-1-20240830 article-title: Genomic evolution, patterns of global dissemination, and interspecies transmission of human and simian T-cell leukemia/lymphotropic viruses publication-title: Genom Res doi: 10.1101/gr.9.6.525 – volume: 2 start-page: 75 year: 2005 ident: R35-1-20240830 article-title: Quantification of the virus-host interaction in human T lymphotropic virus I infection publication-title: Retrovirology doi: 10.1186/1742-4690-2-75 – volume: 32 start-page: 485 year: 2019 ident: R5-1-20240830 article-title: HTLV-1 infection: An emerging risk. pathogenesis, epidemiology, diagnosis and associated diseases publication-title: Rev Esp Quimioter – volume: 111 start-page: 5047 year: 2008 ident: R21-1-20240830 article-title: High frequency of CD4+FoxP3+ cells in HTLV-1 infection: Inverse correlation with HTLV-l-specific CTL response publication-title: Blood doi: 10.1182/blood-2007-10-118539 – volume: 24 start-page: 6058 year: 2005 ident: R4-1-20240830 article-title: Global epidemiology of HTLV-I infection and associated diseases publication-title: Oncogene doi: 10.1038/sj.onc.1208968 – volume: 115 start-page: 1361 year: 2005 ident: R16-1-20240830 article-title: Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease publication-title: J Clin Invest doi: 10.1172/JCI23913 – volume: 9 start-page: 522 year: 2014 ident: R27-1-20240830 article-title: Epigenetic modification of the FoxP3 TSDR in HAM/ TSP decreases the functional suppression of Tregs publication-title: J Neuroimmune Pharmacol doi: 10.1007/s11481-014-9547-z – volume: 9 start-page: 46 year: 2012 ident: R30-1-20240830 article-title: HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals publication-title: Retrovirology doi: 10.1186/1742-4690-9-46 – volume: 30 start-page: 610 year: 2014 ident: R22-1-20240830 article-title: Genes related to antiviral activity, cell migration, and lysis are differentially expressed in CD4+ T cells in human T cell leukemia virus type 1-associated myelopathy/tropical spastic paraparesis patients publication-title: AIDS Res Hum Retroviruses doi: 10.1089/aid.2013.0109 – volume: 119 start-page: 3968 year: 2018 ident: R11-1-20240830 article-title: Human T-lymphotropic virus 1 (HTLV-1) pathogenesis: A systems virology study publication-title: J Cell Biochem doi: 10.1002/jcb.26546 – volume: 118 start-page: 1865 year: 2011 ident: R25-1-20240830 article-title: HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator publication-title: Blood doi: 10.1182/blood-2010-12-326199 – volume: 98 start-page: 721 year: 2001 ident: R31-1-20240830 article-title: High production of interferon γ but not interleukin-2 by human T-lymphotropic virus type I -infected peripheral blood mononuclear cells publication-title: Blood doi: 10.1182/blood.V98.3.721 – volume: 6 start-page: e1000097 year: 2009 ident: R18-1-20240830 article-title: Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement publication-title: PLoS Med doi: 10.1371/journal.pmed.1000097 – volume: 26 start-page: 652 year: 2020 ident: R13-1-20240830 article-title: Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis publication-title: J Neur Virol – volume: 198 start-page: 1875 year: 2003 ident: R40-1-20240830 article-title: Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3 publication-title: J Exp Med doi: 10.1084/jem.20030152 – volume: 46 start-page: 302 year: 1991 ident: R44-1-20240830 article-title: Cytokine induction in HTLV-I associated myelopathy and adult T-cell leukemia: Alternate molecular mechanisms underlying retroviral pathogenesis publication-title: J Cell Biochem doi: 10.1002/jcb.240460405 – volume: 61 start-page: 49 year: 2015 ident: R10-1-20240830 article-title: Neurological manifestations in human T-cell lymphotropic virus type 1 (HTLV-1)-infected individuals without HTLV-1-associated myelopathy/ tropical spastic paraparesis: A longitudinal cohort study publication-title: Clin Infect Dis doi: 10.1093/cid/civ229 – volume: 39 start-page: 623 year: 2019 ident: R14-1-20240830 article-title: Regulatory T cells: The many faces of foxp3 publication-title: J Clin Immunol doi: 10.1007/s10875-019-00684-7 – volume: 22 start-page: 416 year: 2016 ident: R23-1-20240830 article-title: HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors publication-title: J Neurovirol doi: 10.1007/s13365-015-0407-2 – volume: 19 start-page: 578 year: 2015 ident: R42-1-20240830 article-title: T cell receptor signaling pathway is overexpressed in CD4+ T cells from HAM/TSP individuals publication-title: Brazilian J Infect Dis doi: 10.1016/j.bjid.2015.07.008 – volume: 43 start-page: 1109 year: 2010 ident: R20-1-20240830 article-title: In vivo fluctuation of tax, foxp3, CTLA-4, and Gitr mRNA expression in CD4+CD25+ t cells of patients with human T-lymphotropic virus type 1-associated myelopathy publication-title: Brazilian J Med Biol Res doi: 10.1590/S0100-879X2010007500107 – volume: 4 start-page: 586 year: 1998 ident: R33-1-20240830 article-title: Analysis of HTLV-I proviral load in 202 HAM/TSP patients and 243 asymptomatic HTLV-I carriers: High proviral load strongly predisposes to HAM/TSP publication-title: J Neurovirol doi: 10.3109/13550289809114225 |
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| SubjectTerms | htlv-1; htlv-1-associated myelopathy/tropical spastic paraparesis (ham/tsp); foxp3; hbz; tax |
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| Title | Co-expression of HBZ, TAX and FOXp3 and HTLV-1-associated myelopathy/ tropical spastic paraparesis development in HTLV-1-infected individuals: A systematic review |
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