Ilf3 and NF90 associate with the axonal targeting element of Tau mRNA

• Published in: The FASEB journal Vol. 18; no. 14; p. 1761
• Main Authors: Larcher, Jean-Christophe, Gasmi, Laila, Viranaïcken, Wildriss, Eddé, Bernard, Bernard, Rozenn, Ginzburg, Irith, Denoulet, Philippe
• Format: Journal Article
• Language: English
• Published: United States 01.11.2004
• Subjects: 3' Untranslated Regions; Animals; Antibody Specificity; Axons - metabolism; Biological Transport; DNA-Binding Proteins - analysis; DNA-Binding Proteins - isolation & purification; DNA-Binding Proteins - metabolism; Immunohistochemistry; Mice; Microtubule-Associated Proteins - isolation & purification; Neurons - chemistry; Neurons - metabolism; NFATC Transcription Factors; Nuclear Factor 90 Proteins; Nuclear Proteins - analysis; Nuclear Proteins - isolation & purification; Nuclear Proteins - metabolism; Regulatory Sequences, Ribonucleic Acid; RNA Probes; RNA, Messenger - chemistry; RNA, Messenger - metabolism; RNA-Binding Proteins - analysis; RNA-Binding Proteins - immunology; RNA-Binding Proteins - isolation & purification; Sequence Analysis, Protein; tau Proteins - genetics; tau Proteins - metabolism; Transcription Factors - analysis; Transcription Factors - isolation & purification; Transcription Factors - metabolism

In neurons, the selective translocation of Tau mRNA toward axons is due to the presence of a nucleotide sequence located in its 3' untranslated region and serving as axonal targeting element. Using this RNA sequence as a probe by a Northwestern approach, we have detected several proteins that i...