To B12 or not to B12: Five questions on the role of cobalamin in host-microbial interactions

• Published in: PLoS pathogens Vol. 15; no. 1; p. e1007479
• Main Authors: Rowley, Carol A., Kendall, Melissa M.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2019; Public Library of Science (PLoS)
• Subjects: Antibiotics; Bacteria; Biology and Life Sciences; Catabolism; Competition; Coprophagy; E coli; Enzymatic activity; Enzyme activity; Enzymes; Fermentation; Gastrointestinal Microbiome - physiology; Gastrointestinal system; Gastrointestinal tract; Gene expression; Herbivores; Host Microbial Interactions - physiology; Humans; Immunology; Infections; Mammals; Medicine and Health Sciences; Metabolism; Metabolites; Microbial Interactions - physiology; Microbiota; Microorganisms; Operons; Pathogenesis; Pearls; Physical Sciences; Regulatory sequences; Salmonella; Small intestine; Vitamin B 12 - metabolism; Vitamin B 12 - physiology; Vitamin B12; Vitamin deficiency; United States > US; Virginia

Ruminants are heavily colonized with cobalamin-producing microbes in the rumen, a specialized organ that allows fermentation of ingested feed, and this cobalamin is later absorbed in the small intestine [3]. [...]unlike most mammals, cattle are able to use the cobalamin produced by bacteria that col...