Epigallocatechin-3-gallate ameliorates lipopolysaccharide-induced acute thymus involution in mice via AMPK/Sirt1 pathway

• Published in: Microbiology and immunology Vol. 68; no. 8; p. 281
• Main Authors: Su, Qing, Yang, Shu-Ping, Guo, Jun-Ping, Rong, Yi-Ren, Sun, Yun, Chai, Yu-Rong
• Format: Journal Article
• Language: English
• Published: Australia 01.08.2024
• Subjects: AMP-Activated Protein Kinases - metabolism; Animals; Antioxidants - pharmacology; Atrophy; Catechin - analogs & derivatives; Catechin - pharmacology; Female; Lipopolysaccharides; Membrane Potential, Mitochondrial - drug effects; Mice; Reactive Oxygen Species - metabolism; Signal Transduction - drug effects; Sirtuin 1 - metabolism; Thymus Gland - drug effects; Thymus Gland - metabolism; AMPK/Sirt1; thymus; thymocytes; lipopolysaccharide; epigallocatechin‐3‐gallate

The thymus, a site to culture the naïve T lymphocytes, is susceptible to atrophy or involution due to aging, inflammation, and oxidation. Epigallocatechin-3-gallate (EGCG) has been proven to possess anti-inflammatory, antioxidant, and antitumor activity. Here, we investigate the effects of EGCG on t...