Intricate SUMO-based control of the homologous recombination machinery

• Published in: Genes & development Vol. 33; no. 19-20; pp. 1346 - 1354
• Main Authors: Dhingra, Nalini, Zhao, Xiaolan
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.10.2019
• Subjects: Animals; Gene Expression Regulation - genetics; Homologous Recombination - genetics; Humans; Rad51 Recombinase - metabolism; Review; SUMO-1 Protein - metabolism; Sumoylation; genome maintenance; sumoylation; homologous recombination; double-strand break repair

The homologous recombination (HR) machinery plays multiple roles in genome maintenance. Best studied in the context of DNA double-stranded break (DSB) repair, recombination enzymes can cleave, pair, and unwind DNA molecules, and collaborate with regulatory proteins to execute multiple DNA processing...