Expression of cell-cycle regulators (cyclin D1, cyclin E, p27kip1, p57kip2) in papillary thyroid carcinoma

• Published in: Otolaryngology-head and neck surgery Vol. 142; no. 3; p. 332
• Main Authors: Lee, Sang Hyuk, Lee, Jong Kyu, Jin, Sung Min, Lee, Kyung Chul, Sohn, Jin Hee, Chae, Seung Wan, Kim, Dong Hoon
• Format: Journal Article
• Language: English
• Published: England 01.03.2010
• Subjects: Adult; Biomarkers, Tumor - metabolism; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - metabolism; Cross-Sectional Studies; Cyclin D1 - metabolism; Cyclin E - metabolism; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinase Inhibitor p57 - metabolism; Female; Gene Expression Regulation, Neoplastic - physiology; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins - metabolism; Lymphatic Metastasis; Male; Middle Aged; Retrospective Studies; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - metabolism

To evaluate the expression of cell-cycle regulators in papillary thyroid carcinoma in relation to lymph node metastatic features, and to determine whether immunohistochemical staining of cell-cycle markers can predict lymph node metastasis. Cross-sectional study of prior surgical specimens. Academic...