Analysis of transient hypermorphic activity of E(spl)D during R8 specification

• Published in: PloS one Vol. 12; no. 10; p. e0186439
• Main Authors: Majot, Adam T., Bidwai, Ashok P.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 2017; Public Library of Science (PLoS)
• Subjects: Aberration; Animals; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Biology and Life Sciences; Clonal deletion; Dosage; Drosophila; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila melanogaster - growth & development; Drosophila melanogaster - metabolism; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Enhancer Elements, Genetic - genetics; Enhancers; Eye; Gene deletion; Gene expression; Gene Expression Regulation, Developmental; Genetic Loci - genetics; Genotype & phenotype; Hyperactivity; Immunofluorescence; Insects; Kinases; Medicine and Health Sciences; Mutation; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Notch protein; Phases; Phenotype; Phosphorylation; Photoreceptor Cells, Invertebrate - metabolism; Photoreceptors; Physical Sciences; Post-translation; Protein Transport; Proteins; Repressors; Research and Analysis Methods; Retina; Retinogenesis; Signal transduction; Specifications; Translation; West Virginia; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0186439

Drosophila atonal (ato) is required for the specification of founding R8 photoreceptors during retinal development. ato is regulated via dual eye-specific enhancers; ato-3' is subject to initial induction whereas 5'-ato facilitates Notch-mediated autoregulation. Notch is further utilized t...