Association between the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism and Manual Aiming Control in Healthy Subjects

• Published in: PloS one Vol. 9; no. 6; p. e99698
• Main Authors: Lage, Guilherme M., Miranda, Débora M., Romano-Silva, Marco A., Campos, Simone B., Albuquerque, Maicon R., Corrêa, Humberto, Malloy-Diniz, Leandro F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 2014; Public Library of Science (PLoS)
• Subjects: Adult; Biology and Life Sciences; Carriers; Catechol; Catechol O-methyltransferase; Catechol O-Methyltransferase - genetics; Cognition; Cognition & reasoning; Decision making; Dopamine; Emerging markets; Executive Function; Female; Gene polymorphism; Genetic Association Studies; Genetics; Genotypes; Healthy Volunteers; Humans; Male; Medicine and Health Sciences; Methyltransferase; Motor Activity - genetics; Motor task performance; Polymorphism; Polymorphism, Single Nucleotide - genetics; Single-nucleotide polymorphism; Social Sciences

Prefrontal dopamine is catabolized by the catechol-O-methyltransferase (COMT) enzyme. Current evidence suggests that the val/met single nucleotide polymorphism in the COMT gene can predict the efficiency of executive cognition in humans. Individuals carrying the val allele perform more poorly becaus...