Irreversible CYP3A inhibition accompanied by plasma protein-binding displacement: a comparative analysis in subjects with normal and impaired liver function - Orlando, R; De Martin, S; Pegoraro, P; Quintieri, L; Palatini, P (Clinical pharmacology and therapeutics, 2009)
Keywords: Adult; Aged; Blood Proteins - metabolism; Cross-Over Studies; Cytochrome P-450 CYP3A - metabolism; Cytochrome P-450 CYP3A Inhibitors; Double-Blind Method; Enzyme Inhibitors - metabolism; Enzyme Inhibitors - pharmacology; Erythromycin - metabolism; Erythromycin - pharmacology; Humans; Liver - drug effects; Liver - enzymology; Liver - physiology; Liver Diseases - enzymology; Liver Diseases - physiopathology; Male; Middle Aged; Protein Binding - drug effects; Protein Binding - physiology; Quinine - metabolism; Quinine - pharmacology