Regulated Expression of PTPRJ by COX-2/PGE2 Axis in Endothelial Cells

• Published in: PloS one Vol. 9; no. 12; p. e114996
• Main Authors: Xu, Xiaobing, Lan, Wenya, Jin, Xinxin, Wang, Bin, Yan, Hongbo, Chen, Xi, Lai, Xiaowei, Zhang, Li, Zhang, Xiaohua, Li, Zhaoshen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 2014; Public Library of Science (PLoS)
• Subjects: Angiogenesis; Animals; Bioinformatics; Biology and Life Sciences; Breast cancer; Carotid arteries; Celecoxib; Cell adhesion & migration; Cells, Cultured; Correlation; Correlation coefficient; Correlation coefficients; COX-2 inhibitors; Cyclooxygenase 2 - genetics; Cyclooxygenase 2 - metabolism; Cyclooxygenase 2 Inhibitors - pharmacology; Cyclooxygenase-2; Disease Models, Animal; Endothelial cells; Endothelial Cells - cytology; Endothelial Cells - metabolism; Enzymes; Gastroenterology; Gene expression; Gene Expression Regulation - drug effects; Genetic Vectors - genetics; Genetic Vectors - metabolism; Genomes; Geriatrics; Hepatology; Hospitals; Human Umbilical Vein Endothelial Cells; Humans; Hyperplasia; Hyperplasia - metabolism; Hyperplasia - pathology; Injury prevention; Kinases; Laboratories; Male; Medicine and Health Sciences; Morphology; Overexpression; Phosphatase; Plasmids; Polymerase chain reaction; Prostaglandin E2; Proteins; Proteomics; Pyrazoles - pharmacology; Rabbits; Receptor-Like Protein Tyrosine Phosphatases, Class 3 - genetics; Receptor-Like Protein Tyrosine Phosphatases, Class 3 - metabolism; Regulators; RNA, Messenger - metabolism; Rodents; Signal transduction; Signaling; Sulfonamides - pharmacology; Transfection; Tumors; Vascular endothelial growth factor; Veins & arteries; Western blotting

This study was designed to examine a novel role of COX-2/PGE2 signaling as a regulator of PTPRJ expression in endothelial cells. A bioinformatics analysis of a whole genome array was carried out to search for regulators of PTPRJ expression in endothelial cells. PTPRJ expression was also measured in...